From a3c89df78aa414878030aeb56b48b4b87ee7847b Mon Sep 17 00:00:00 2001
From: Lucas PAOLI <lucas.paoli@pasteur.fr>
Date: Wed, 22 Nov 2023 15:19:28 +0100
Subject: [PATCH] Update pif.md according to Hackaton guidelines, see
https://gitlab.pasteur.fr/mdm-lab/wiki/-/issues/233
---
content/3.defense-systems/pif.md | 28 ++++++++++++++++------------
1 file changed, 16 insertions(+), 12 deletions(-)
diff --git a/content/3.defense-systems/pif.md b/content/3.defense-systems/pif.md
index 78931e44..6ac8a094 100644
--- a/content/3.defense-systems/pif.md
+++ b/content/3.defense-systems/pif.md
@@ -10,9 +10,25 @@ tableColumns:
Activator: Unknown
Effector: Membrane disrupting (?)
PFAM: PF07693
+contributors:
+ - Lucas Paoli
+relevantAbstracts:
+ - doi: 10.1007/BF00327934
+ - doi: 10.1016/j.virol.2004.06.001
+ - doi: 10.1128/jb.173.20.6507-6514.1991
+ - doi: 10.1038/newbio231037a0
---
# Pif
+
+## Description
+
+The Pif system (Phage Inhibition by F factors) was first described by Morisson & Malamy, 1971 :ref{doi=10.1038/newbio231037a0}. The Pif region of the F plasmid inhibits the phage T7 through abortive infection :ref{doi=10.1038/newbio231037a0,10.1007/BF00327934}.
+
+## Molecular mechanisms
+
+PifA was later identified as the effector of the abortive infection :ref{doi=10.1128/jb.173.20.6507-6514.1991,10.1016/j.virol.2004.06.001} through nucleotide depletion by increased membrane permeability (also known as "leakage").
+
## Example of genomic structure
The Pif system is composed of 2 proteins: PifC and, PifA.
@@ -75,15 +91,3 @@ end
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
-## Relevant abstracts
-
-::relevant-abstracts
----
-items:
- - doi: 10.1007/BF00327934
- - doi: 10.1016/j.virol.2004.06.001
- - doi: 10.1128/jb.173.20.6507-6514.1991
-
----
-::
-
--
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