diff --git a/content/3.defense-systems/kiwa.md b/content/3.defense-systems/kiwa.md index c27a42ee2588c9ef4a8e0ce04208938828a9d8fa..ea4fad102ea5d97bc5d1357fd0f3938dd5c3d7df 100644 --- a/content/3.defense-systems/kiwa.md +++ b/content/3.defense-systems/kiwa.md @@ -10,9 +10,23 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF16162 +contributors: + - Lucas Paoli +relevantAbstracts: + - doi: 10.1126/science.aar4120 + - doi: 10.1101/2023.02.26.530102 --- # Kiwa + +## Description + +The Kiwa antiviral defense system was first described by Doron et al. 2018 :ref{doi=10.1126/science.aar4120} and further described by Todeschini et al. 2023 :ref{doi=10.1101/2023.02.26.530102}. It named after one of the divine guardians of the ocean in the MÄori traditions. + +## Molecular mechanisms + +Kiwa is composed of two proteins: KwaA and KwaB. KwaA detects phage infection by detecting the inhibition of the host RNA polymerase by phages. This triggers the reponse by KwaB, which decreases phage DNA replication through a RecBCD-depdendent pathway :ref{doi=10.1101/2023.02.26.530102}.. + ## Example of genomic structure The Kiwa system is composed of 2 proteins: KwaA and, KwaB. @@ -76,13 +90,4 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts - -::relevant-abstracts ---- -items: - - doi: 10.1126/science.aar4120 - ---- -::