From a6babcc33b2f67123cbcbcadf5468eb5f9f18c3f Mon Sep 17 00:00:00 2001
From: Lucas PAOLI <lucas.paoli@pasteur.fr>
Date: Wed, 22 Nov 2023 11:25:35 +0100
Subject: [PATCH] Update kiwa.md according to Hackaton guidelines, see
 https://gitlab.pasteur.fr/mdm-lab/wiki/-/issues/236

---
 content/3.defense-systems/kiwa.md | 23 ++++++++++++++---------
 1 file changed, 14 insertions(+), 9 deletions(-)

diff --git a/content/3.defense-systems/kiwa.md b/content/3.defense-systems/kiwa.md
index c27a42ee..ea4fad10 100644
--- a/content/3.defense-systems/kiwa.md
+++ b/content/3.defense-systems/kiwa.md
@@ -10,9 +10,23 @@ tableColumns:
     Activator: Unknown
     Effector: Unknown
     PFAM: PF16162
+contributors: 
+  - Lucas Paoli
+relevantAbstracts:
+  - doi: 10.1126/science.aar4120
+  - doi: 10.1101/2023.02.26.530102
 ---
 
 # Kiwa
+
+## Description
+
+The Kiwa antiviral defense system was first described by Doron et al. 2018 :ref{doi=10.1126/science.aar4120} and further described by Todeschini et al. 2023 :ref{doi=10.1101/2023.02.26.530102}. It named after one of the divine guardians of the ocean in the Māori traditions.
+
+## Molecular mechanisms
+
+Kiwa is composed of two proteins: KwaA and KwaB. KwaA detects phage infection by detecting the inhibition of the host RNA polymerase by phages. This triggers the reponse by KwaB, which decreases phage DNA replication through a RecBCD-depdendent pathway :ref{doi=10.1101/2023.02.26.530102}..
+
 ## Example of genomic structure
 
 The Kiwa system is composed of 2 proteins: KwaA and, KwaB.
@@ -76,13 +90,4 @@ end
     style Title3 fill:none,stroke:none,stroke-width:none
     style Title4 fill:none,stroke:none,stroke-width:none
 </mermaid>
-## Relevant abstracts
-
-::relevant-abstracts
----
-items:
-    - doi: 10.1126/science.aar4120
-
----
-::
 
-- 
GitLab