From a736f7be7a4ab31bfb9bcf52dc467bead763147e Mon Sep 17 00:00:00 2001
From: ftesson <florian.tesson@cri-paris.org>
Date: Wed, 10 Jan 2024 15:55:08 +0100
Subject: [PATCH] Update zorya.md
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content/3.defense-systems/zorya.md | 24 +++++++++++++++++++++++-
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# Zorya
+
+## Description
+
+The Zorya defense system was discovered in 2018 :ref{doi=10.1126/science.aar4120} among other systems.
+
+The Zorya defense system is composed of two protein ZorA and ZorB in all the subtypes with different other proteins (ZorC + ZorD type I, ZorE type II or ZorF + ZorG type III).
+
+## Molecular mechanism
+
+For Zorya type I:
+
+ZorA and ZorB forms an transmembrane heteromer 5:2 (A:B) acting as a peptidoglycin-binding rotary motor :ref{doi=10.1101/2023.12.18.572097}. The structure show that the 5 ZorA proteins form a long tail inside the cytoplasm. Part of this tail has amino acid homology with the core signaling unit of the bacterial chemosensory array :ref{doi=10.1016/j.sbi.2023.102565} suggesting that the ZorA tail is responsible of the activation of ZorC and ZorD.
+
+On the other hand, ZorC and ZorD interact with DNA :ref{doi=10.1101/2023.12.18.572097} and ZorD act as a ATP dependant nuclease.
+
+With all those results :ref{doi=10.1101/2023.12.18.572097}, the suggested mechanism is:
+
+- Detection of the phage infection by the ZorAB complex (depressed cell wall or inner membrane curvature)
+- Signal transduction from ZorA tail to ZorC and ZorD
+- DNA binding by ZorC/D and DNA cleavage by ZorD close to the injection site.
+
+
## Example of genomic structure
A total of 2 subsystems have been described for the Zorya system.
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items:
- doi: 10.1093/nar/gkab883
- doi: 10.1126/science.aar4120
-
+ - doi: 10.1101/2023.12.18.572097
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::
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