From af95ee43330dc6d2ec0864d96bea26149b12ee98 Mon Sep 17 00:00:00 2001
From: ftesson <florian.tesson@cri-paris.org>
Date: Wed, 20 Dec 2023 15:27:29 +0100
Subject: [PATCH] shosta_hackaton
---
content/3.defense-systems/shosta.md | 24 ++++++++++++++----------
1 file changed, 14 insertions(+), 10 deletions(-)
diff --git a/content/3.defense-systems/shosta.md b/content/3.defense-systems/shosta.md
index 1e3c7bd8..548b16d2 100644
--- a/content/3.defense-systems/shosta.md
+++ b/content/3.defense-systems/shosta.md
@@ -10,9 +10,23 @@ tableColumns:
Activator: Unknown
Effector: Unknown
PFAM: PF02481
+relevantAbstracts:
+ - doi: 10.1016/j.chom.2022.09.017
+ - doi: 10.1016/j.chom.2022.02.018
+ - doi: 10.1101/gr.133850.111
---
# ShosTA
+
+## Description
+
+ShosTA system was first described as a Toxin/Antitoxin system in 2012 :ref{doi=10.1101/gr.133850.111} without demonstration of antiphage activity. In 2022, a paper described the same system as "DprA + PRTase" inside P2 like prophages and prooves its antiphage activity. Finally, the antiphage activity was also prooved in another study with the original name ShosTA :ref{doi=10.1016/j.chom.2022.09.017}.
+
+This system is composed of two protein: ShosT and ShosA encoding for Hydrolase/PRTase and DprA (nucleotid binding) respectively.
+
+## Molecular mechanism
+The ShosTA system is a toxin (ShosT) antitoxin (ShosA) system. The domains of ShosT (Hydrolase and PRTase) allows us to hypothesize a toxicity linked to host protein degradation.
+
## Example of genomic structure
The ShosTA system is composed of 2 proteins: ShosA and, ShosT.
@@ -87,15 +101,5 @@ end
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
-## Relevant abstracts
-::relevant-abstracts
----
-items:
- - doi: 10.1016/j.chom.2022.09.017
- - doi: 10.1016/j.chom.2022.09.017
- - doi: 10.1101/gr.133850.111
-
----
-::
--
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