diff --git a/content/3.defense-systems/radar.md b/content/3.defense-systems/radar.md index 6464e4cb77c9c8139b0d6224e47eec85ae2f5b54..4e3dec791186b85a104c76f1f60e5a4a6bc7cfda 100644 --- a/content/3.defense-systems/radar.md +++ b/content/3.defense-systems/radar.md @@ -26,7 +26,7 @@ RADAR (Restriction by an Adenosine Deaminase Acting on RNA) is comprised of two ## Molecular mechanism In the initial study describing RADAR, RADAR was found to perform RNA editing of adenosine to inosine during phage infection :ref{doi=10.1126/science.aba0372}. Editing sites were broadly distributed on the host transcriptome, which could prove deleterious leading to observed growth arrest of RADAR upon phage infection. Â -Further structural studies revealed potential different mechanism of actions. :ref{doi=10.1016/j.cell.2023.01.026} :ref{doi=10.1016/j.cell.2023.01.012}. RdrA and RdrB assemble to form a giant 10 MDa complex. The RADAR defense system limits phage replication by catalyzing ATP deamination. Within this system, RdrB functions as an adenosine deaminase, leading to the buildup of ITP and dITP. RdrA induces RdrB activity and potentially regulates the detection of phage infections. +Further structural studies revealed potential different mechanism of actions :ref{doi=10.1016/j.cell.2023.01.026, 10.1016/j.cell.2023.01.012}. RdrA and RdrB assemble to form a giant 10 MDa complex. The RADAR defense system limits phage replication by catalyzing ATP deamination. Within this system, RdrB functions as an adenosine deaminase, leading to the buildup of ITP (Inosine Tri-Phosphate) and dITP. RdrA induces RdrB activity and potentially regulates the detection of phage infections. ## Example of genomic structure