From b8e2a0a7df2ca73ca29d6528dab19c1656321f7f Mon Sep 17 00:00:00 2001
From: Jean CURY <jean.cury@pasteur.fr>
Date: Tue, 28 Nov 2023 12:50:46 +0100
Subject: [PATCH] Update radar.md
---
content/3.defense-systems/radar.md | 2 +-
1 file changed, 1 insertion(+), 1 deletion(-)
diff --git a/content/3.defense-systems/radar.md b/content/3.defense-systems/radar.md
index 6464e4cb..4e3dec79 100644
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+++ b/content/3.defense-systems/radar.md
@@ -26,7 +26,7 @@ RADAR (Restriction by an Adenosine Deaminase Acting on RNA) is comprised of two
## Molecular mechanism
In the initial study describing RADAR, RADAR was found to perform RNA editing of adenosine to inosine during phage infection :ref{doi=10.1126/science.aba0372}. Editing sites were broadly distributed on the host transcriptome, which could prove deleterious leading to observed growth arrest of RADAR upon phage infection. Â
-Further structural studies revealed potential different mechanism of actions. :ref{doi=10.1016/j.cell.2023.01.026} :ref{doi=10.1016/j.cell.2023.01.012}. RdrA and RdrB assemble to form a giant 10 MDa complex. The RADAR defense system limits phage replication by catalyzing ATP deamination. Within this system, RdrB functions as an adenosine deaminase, leading to the buildup of ITP and dITP. RdrA induces RdrB activity and potentially regulates the detection of phage infections.
+Further structural studies revealed potential different mechanism of actions :ref{doi=10.1016/j.cell.2023.01.026, 10.1016/j.cell.2023.01.012}. RdrA and RdrB assemble to form a giant 10 MDa complex. The RADAR defense system limits phage replication by catalyzing ATP deamination. Within this system, RdrB functions as an adenosine deaminase, leading to the buildup of ITP (Inosine Tri-Phosphate) and dITP. RdrA induces RdrB activity and potentially regulates the detection of phage infections.
## Example of genomic structure
--
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