diff --git a/content/3.defense-systems/paris.md b/content/3.defense-systems/paris.md index 166b92efe5e377fe9c8cdf781f473d8952c839f9..ab1578d2baffaa765adfafec62e830a30864fa3c 100644 --- a/content/3.defense-systems/paris.md +++ b/content/3.defense-systems/paris.md @@ -9,17 +9,21 @@ tableColumns: Sensor: Sensing of phage protein Activator: Unknown Effector: Unknown +contributors: + - Lucas Paoli relevantAbstracts: - - doi: 10.1016/j.chom.2022.02.018 + - doi: 10.1016/j.chom.2022.02.018 --- # Paris ## Description -PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. PARIS is found in 4% of prokaryotic genomes. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion (1). +PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion :ref{doi=10.1016/j.chom.2022.02.018}. -This system relies on an unknown [Abortive infection](/general-concepts/abortive-infection) mechanism to trigger growth arrest upon sensing a phage-encoded protein (Ocr). Interestingly, the Ocr protein has been found to inhibit R-M systems and BREX systems, making PARIS a suitable defense mechanism against RM resistant and/or BREX resistant phages (1, 2, 3). +## Molecular mechanisms + +This system relies on an unknown [Abortive infection](/general-concepts/abortive-infection) mechanism to trigger growth arrest upon sensing a phage-encoded protein (Ocr). Interestingly, the Ocr protein has been found to inhibit R-M systems and BREX systems, making PARIS a suitable defense mechanism against RM resistant and/or BREX resistant phages :ref{doi=0.1016/j.chom.2022.02.018,10.1093/nar/gkaa510,10.1007/BF01036001}. ## Example of genomic structure