diff --git a/content/3.defense-systems/radar.md b/content/3.defense-systems/radar.md index b00ea0c3103aa1d375ea2287b35a7ef4c7a86060..2ac7323f8358f5f45d7f05093604bc2e610bf0ec 100644 --- a/content/3.defense-systems/radar.md +++ b/content/3.defense-systems/radar.md @@ -26,7 +26,7 @@ RADAR (Restriction by an Adenosine Deaminase Acting on RNA) is comprised of two ## Molecular mechanism In the initial study describing RADAR, RADAR was found to perform RNA editing of adenosine to inosine during phage infection :ref{doi=10.1126/science.aba0372}. Editing sites were broadly distributed on the host transcriptome, which could prove deleterious leading to observed growth arrest of RADAR upon phage infection. Â -Further structural studies revealed potential different mechanism of actions :ref{doi=10.1016/j.cell.2023.01.026, 10.1016/j.cell.2023.01.012}. RdrA and RdrB assemble to form a giant 10 MDa complex. The RADAR defense system limits phage replication by catalyzing ATP deamination. Within this system, RdrB functions as an adenosine deaminase, leading to the buildup of ITP (Inosine Tri-Phosphate) and dITP. RdrA induces RdrB activity and potentially regulates the detection of phage infections. +Further structural studies revealed potential different mechanism of actions :ref{doi=10.1016/j.cell.2023.01.026,10.1016/j.cell.2023.01.012}. RdrA and RdrB assemble to form a giant 10 MDa complex. The RADAR defense system limits phage replication by catalyzing ATP deamination. Within this system, RdrB functions as an adenosine deaminase, leading to the buildup of ITP (Inosine Tri-Phosphate) and dITP. RdrA induces RdrB activity and potentially regulates the detection of phage infections. ## Example of genomic structure