From dab4e44651f91ee7d4096352ff814b93bccc499c Mon Sep 17 00:00:00 2001
From: ftesson <florian.tesson@cri-paris.org>
Date: Tue, 9 Jan 2024 16:31:13 +0100
Subject: [PATCH] Update abie.md
---
content/3.defense-systems/abie.md | 35 ++++++++++++++++++-------------
1 file changed, 20 insertions(+), 15 deletions(-)
diff --git a/content/3.defense-systems/abie.md b/content/3.defense-systems/abie.md
index e8f45950..a74e3561 100644
--- a/content/3.defense-systems/abie.md
+++ b/content/3.defense-systems/abie.md
@@ -10,18 +10,34 @@ tableColumns:
Activator: Unknown
Effector: Unknown
PFAM: PF08843, PF09407, PF09952, PF11459, PF13338, PF17194
+contributors:
+ - Florian Tesson
+relevantAbstracts:
+ - doi: 10.1023/A:1002027321171
+ - doi: 10.1016/j.mib.2005.06.006
+ - doi: 10.1093/nar/gkt1419
+ - doi: 10.1128/aem.61.12.4321-4328.1995
---
# AbiE
-AbiE is a family of an anti-phage defense systems. They act through a Toxin-Antitoxin mechanism, and are comprised of a pair of genes, with one gene being toxic while the other confers immunity to this toxicity.
-It is classified as an Abortive infection system.
+## AbiE
+AbiE was discovered in 1995 on a Lactococcal plasmid :ref{doi=10.1128/aem.61.12.4321-4328.1995} together with [AbiN](/defense-systems/abin).
+
+AbiE is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry :ref{doi=10.1016/j.mib.2005.06.006}. AbiE is classified as abortive infection in :ref{doi=10.1016/j.mib.2023.102312}.
+
+AbiE is composed of two proteins: AbiEi and AbiEii. AbiEii is annotated as a nucleotidyltransferase.
+
+
+
+
## Molecular mechanism
+AbiE is a family of an anti-phage defense systems. They act through a Toxin-Antitoxin mechanism, and are comprised of a pair of genes, with one gene being toxic while the other confers immunity to this toxicity :ref{doi=10.1093/nar/gkt1419}.
-AbiE systems are encoded by two mandatory genes, abiEi and abiEii (1,2). The latter encodes for AbiEii, a GTP-binding nucleotidyltransferase (NTase) which expression induce a reversible growth arrest. On the other hand, abiEi encodes for a AbiEi a transcriptional autorepressor that binds to the promoter of the abiE operon.
+AbiEii is a GTP-binding nucleotidyltransferase (NTase) which expression induce a reversible growth arrest :ref{doi=10.1093/nar/gkt1419}. On the other hand, AbiEi js a transcriptional autorepressor that binds to the promoter of the abiE operon.
-Based on this mechanisms, AbiE systems are classified as Type IV Toxin-Antitoxin system, where the antitoxin and toxin are both proteins that do not directly interact with each other.
+Based on this mechanisms, AbiE systems are classified as Type IV Toxin-Antitoxin system, where the antitoxin and toxin are both proteins that do not directly interact with each other :ref{doi=10.1093/nar/gkt1419}.
## Example of genomic structure
@@ -86,15 +102,4 @@ end
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
-## Relevant abstracts
-
-::relevant-abstracts
----
-items:
- - doi: 10.1023/A:1002027321171
- - doi: 10.1016/j.mib.2005.06.006
- - doi: 10.1093/nar/gkt1419
-
----
-::
--
GitLab