From ded27b76c9f8468ddac1762fa7170423a4a08ca3 Mon Sep 17 00:00:00 2001
From: Lucas PAOLI <lucas.paoli@pasteur.fr>
Date: Tue, 23 Jan 2024 11:15:51 +0100
Subject: [PATCH] Update paris.md according to Hackaton guidelines, see...
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content/3.defense-systems/paris.md | 10 +++++++---
1 file changed, 7 insertions(+), 3 deletions(-)
diff --git a/content/3.defense-systems/paris.md b/content/3.defense-systems/paris.md
index 166b92ef..ab1578d2 100644
--- a/content/3.defense-systems/paris.md
+++ b/content/3.defense-systems/paris.md
@@ -9,17 +9,21 @@ tableColumns:
Sensor: Sensing of phage protein
Activator: Unknown
Effector: Unknown
+contributors:
+ - Lucas Paoli
relevantAbstracts:
- - doi: 10.1016/j.chom.2022.02.018
+ - doi: 10.1016/j.chom.2022.02.018
---
# Paris
## Description
-PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. PARIS is found in 4% of prokaryotic genomes. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion (1).
+PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion :ref{doi=10.1016/j.chom.2022.02.018}.
-This system relies on an unknown [Abortive infection](/general-concepts/abortive-infection) mechanism to trigger growth arrest upon sensing a phage-encoded protein (Ocr). Interestingly, the Ocr protein has been found to inhibit R-M systems and BREX systems, making PARIS a suitable defense mechanism against RM resistant and/or BREX resistant phages (1, 2, 3).Â
+## Molecular mechanisms
+
+This system relies on an unknown [Abortive infection](/general-concepts/abortive-infection) mechanism to trigger growth arrest upon sensing a phage-encoded protein (Ocr). Interestingly, the Ocr protein has been found to inhibit R-M systems and BREX systems, making PARIS a suitable defense mechanism against RM resistant and/or BREX resistant phages :ref{doi=0.1016/j.chom.2022.02.018,10.1093/nar/gkaa510,10.1007/BF01036001}.Â
## Example of genomic structure
--
GitLab