diff --git a/content/3.defense-systems/rosmerta.md b/content/3.defense-systems/rosmerta.md index cca150e7cb982623f3b606d9bb2d8d6244256d88..ef93f8a4d0c468b195267bf8feaa1e7b87de7f3f 100644 --- a/content/3.defense-systems/rosmerta.md +++ b/content/3.defense-systems/rosmerta.md @@ -10,9 +10,22 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF01381, PF06114, PF12844, PF13443, PF13560 +contributors: + - Lucas Paoli +relevantAbstracts: + - doi: 10.1016/j.chom.2022.09.017 --- # RosmerTA + +## Description + +The RosmerTA system was found to have antiviral activity and named after Gallo-Roman goddess of fertility by Millman et al. 2022 :ref{doi=10.1016/j.chom.2022.09.017}. + +## Molecular mechanisms + +The RosmerTA system encodes a Zn-peptidase and a toxin of unknown function :ref{doi=10.1016/j.chom.2022.09.017} and was later found to induce membrane depolarization :ref{doi=10.1073/pnas.2305393120}. + ## Example of genomic structure The RosmerTA is composed of 2 proteins: RmrT and RmrA. @@ -77,13 +90,3 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts - -::relevant-abstracts ---- -items: - - doi: 10.1016/j.chom.2022.09.017 - ---- -:: - diff --git a/content/3.defense-systems/rst_tir-nlr.md b/content/3.defense-systems/rst_tir-nlr.md index b2ec23e6cce209e74e9af6437b6792d2b69700d5..2736b4fa6038ecdccd7398aa24fdd9a2f4b9a6ba 100644 --- a/content/3.defense-systems/rst_tir-nlr.md +++ b/content/3.defense-systems/rst_tir-nlr.md @@ -10,9 +10,24 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF13676 +contributors: + - Lucas Paoli +relevantAbstracts: + - doi: 10.1016/j.chom.2022.02.018 --- # Rst_TIR-NLR + +## Description + +The Rst_TIR-NLR system is named after the first author of the paper describing it (Rousset et al. 2022) and the domains of the only protein it contains (TIR, toll-interleukin-1 receptor, and NLR, nucleotide-binding leucine rich repeat receptor) :ref{doi=10.1016/j.chom.2022.02.018}. + +This system is very similar to other bacterial defense systems: bNACHT (https://defense-finder.pasteur.cloud/wiki/defense-systems/nlr), CARD_NLR (https://defense-finder.pasteur.cloud/wiki/defense-systems/card_nlr), Avs (AVAST) (https://defense-finder.pasteur.cloud/wiki/defense-systems/avs). + +## Molecular mechanisms + +As far as we are aware, the molecular mechanism is unknown. However, the molecular mechanism of closely related systems was previously studied. See bNACHT (https://defense-finder.pasteur.cloud/wiki/defense-systems/nlr), CARD_NLR (https://defense-finder.pasteur.cloud/wiki/defense-systems/card_nlr) and Avs (AVAST) (https://defense-finder.pasteur.cloud/wiki/defense-systems/avs) + ## Example of genomic structure The Rst_TIR-NLR is composed of 1 protein: TIR. @@ -74,13 +89,3 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts - -::relevant-abstracts ---- -items: - - doi: 10.1016/j.chom.2022.02.018 - ---- -:: - diff --git a/deploy/meilisearch/values.development.yaml b/deploy/meilisearch/values.development.yaml index 1391c8de6efbe55d8b9bab5efa9c48c4f1ccb8a7..de47d7f485b092bb1e144cb1ec61031a48822912 100644 --- a/deploy/meilisearch/values.development.yaml +++ b/deploy/meilisearch/values.development.yaml @@ -12,8 +12,8 @@ meilisearch: size: "1Gi" resources: limits: - cpu: 1500m + cpu: 2000m memory: 2Gi requests: - cpu: 1000m - memory: 800Mi + cpu: 1500m + memory: 1Gi