diff --git a/content/2.defense-systems/gp29_gp30.md b/content/2.defense-systems/phrann_gp29_gp30.md similarity index 72% rename from content/2.defense-systems/gp29_gp30.md rename to content/2.defense-systems/phrann_gp29_gp30.md index 7a5b09378076e60b08e6e30afe7fcb4939881984..26f84206f396ea5dde18454ba485545aca08b53d 100644 --- a/content/2.defense-systems/gp29_gp30.md +++ b/content/2.defense-systems/phrann_gp29_gp30.md @@ -1,5 +1,5 @@ --- -title: gp29_gp30 +title: phrann_gp29_gp30 tableColumns: article: doi: 10.1038/nmicrobiol.2016.251 @@ -7,27 +7,27 @@ tableColumns: Temperate phages are common, and prophages are abundant residents of sequenced bacterial genomes. Mycobacteriophages are viruses that infect mycobacterial hosts including Mycobacterium tuberculosis and Mycobacterium smegmatis, encompass substantial genetic diversity and are commonly temperate. Characterization of ten Cluster N temperate mycobacteriophages revealed at least five distinct prophage-expressed viral defence systems that interfere with the infection of lytic and temperate phages that are either closely related (homotypic defence) or unrelated (heterotypic defence) to the prophage. Target specificity is unpredictable, ranging from a single target phage to one-third of those tested. The defence systems include a single-subunit restriction system, a heterotypic exclusion system and a predicted (p)ppGpp synthetase, which blocks lytic phage growth, promotes bacterial survival and enables efficient lysogeny. The predicted (p)ppGpp synthetase coded by the Phrann prophage defends against phage Tweety infection, but Tweety codes for a tetrapeptide repeat protein, gp54, which acts as a highly effective counter-defence system. Prophage-mediated viral defence offers an efficient mechanism for bacterial success in host–virus dynamics, and counter-defence promotes phage co-evolution. --- -# gp29_gp30 -# gp29_gp30 +# phrann_gp29_gp30 +# phrann_gp29_gp30 ## Example of genomic structure -The gp29_gp30 system is composed of 2 proteins: gp30 and, gp29. +The phrann_gp29_gp30 system is composed of 2 proteins: gp30 and, gp29. Here is an example found in the RefSeq database: -{max-width=750px} +{max-width=750px} -gp29_gp30 system in the genome of *Mycobacterium tuberculosis* (GCF_002448055.1) is composed of 2 proteins: gp29 (WP_003407164.1)and, gp30 (WP_003407167.1). +phrann_gp29_gp30 system in the genome of *Mycobacterium tuberculosis* (GCF_002448055.1) is composed of 2 proteins: gp29 (WP_003407164.1)and, gp30 (WP_003407167.1). ## Distribution of the system among prokaryotes -The gp29_gp30 system is present in a total of 35 different species. +The phrann_gp29_gp30 system is present in a total of 35 different species. Among the 22k complete genomes of RefSeq, this system is present in 314 genomes (1.4 %). -{max-width=750px} +{max-width=750px} -*Proportion of genome encoding the gp29_gp30 system for the 14 phyla with more than 50 genomes in the RefSeq database.* +*Proportion of genome encoding the phrann_gp29_gp30 system for the 14 phyla with more than 50 genomes in the RefSeq database.* ## Relevant abstracts diff --git a/public/gp29_gp30/Distribution_gp29_gp30.svg b/public/phrann_gp29_gp30/Distribution_phrann_gp29_gp30.svg similarity index 100% rename from public/gp29_gp30/Distribution_gp29_gp30.svg rename to public/phrann_gp29_gp30/Distribution_phrann_gp29_gp30.svg diff --git a/public/gp29_gp30/gp29_gp30.svg b/public/phrann_gp29_gp30/phrann_gp29_gp30.svg similarity index 100% rename from public/gp29_gp30/gp29_gp30.svg rename to public/phrann_gp29_gp30/phrann_gp29_gp30.svg