From ec6635016f539725bebb335e1509a3de0f3c382d Mon Sep 17 00:00:00 2001
From: Lucas PAOLI <lucas.paoli@pasteur.fr>
Date: Wed, 22 Nov 2023 17:31:28 +0100
Subject: [PATCH] Update lit.md according to Hackaton guidelines, see
https://gitlab.pasteur.fr/mdm-lab/wiki/-/issues/220
---
content/3.defense-systems/lit.md | 29 +++++++++++++++++------------
1 file changed, 17 insertions(+), 12 deletions(-)
diff --git a/content/3.defense-systems/lit.md b/content/3.defense-systems/lit.md
index e64c9beb..32da3b98 100644
--- a/content/3.defense-systems/lit.md
+++ b/content/3.defense-systems/lit.md
@@ -10,9 +10,26 @@ tableColumns:
Activator: Direct
Effector: Other (Cleaves an elongation factor, inhibiting cellular translation
PFAM: PF10463
+contributors:
+ - Lucas Paoli
+relevantAbstracts:
+ - doi: 10.1128/jb.169.3.1232-1238.1987
+ - doi: 10.1128/jb.170.5.2056-2062.1988
+ - doi: 10.1073/pnas.91.2.802
+ - doi: 10.1074/jbc.M002546200
+ - doi: 10.1186/1743-422X-7-360
---
# Lit
+
+## Description
+
+Lit was first identified in 1989 :ref{doi=10.1128/jb.169.3.1232-1238.1987}, stands for late inhibitors of T4, and was found to inhibit phage T4 in Escherichia coli (K12). The Lit gene is found in the e14 cryptic prophage :ref{doi=10.1128/jb.170.5.2056-2062.1988}. Lit is also partially active against other T-even phages :ref{doi=10.1073/pnas.91.2.802}.
+
+## Molecular mechanisms
+
+The Lit system detects cleaves EF-Tu translation factor :ref{doi=10.1073/pnas.91.2.802} at a late stage of phage maturation, when the major capsid protein binds to EF-Tu and triggers its cleavage by Lit :ref{doi=10.1074/jbc.M002546200}. As a result, the translation is inhbited, which ultimately leads to cell death. Lit is part of the abortive infection category of defense systems.
+
## Example of genomic structure
The Lit system is composed of one protein: Lit.
@@ -68,15 +85,3 @@ end
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
-## Relevant abstracts
-
-::relevant-abstracts
----
-items:
- - doi: 10.1073/pnas.91.2.802
- - doi: 10.1074/jbc.M002546200
- - doi: 10.1186/1743-422X-7-360
-
----
-::
-
--
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