From f386ccf78e8c4b68806163baca1eb85d6e43a590 Mon Sep 17 00:00:00 2001 From: ftesson <florian.tesson@cri-paris.org> Date: Mon, 15 Jan 2024 10:38:53 +0100 Subject: [PATCH] Update paris.md --- content/3.defense-systems/paris.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/content/3.defense-systems/paris.md b/content/3.defense-systems/paris.md index 0ab10f90..ab1578d2 100644 --- a/content/3.defense-systems/paris.md +++ b/content/3.defense-systems/paris.md @@ -19,11 +19,11 @@ relevantAbstracts: ## Description -PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion (1). +PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion :ref{doi=10.1016/j.chom.2022.02.018}. ## Molecular mechanisms -This system relies on an unknown [Abortive infection](/general-concepts/abortive-infection) mechanism to trigger growth arrest upon sensing a phage-encoded protein (Ocr). Interestingly, the Ocr protein has been found to inhibit R-M systems and BREX systems, making PARIS a suitable defense mechanism against RM resistant and/or BREX resistant phages (1, 2, 3). +This system relies on an unknown [Abortive infection](/general-concepts/abortive-infection) mechanism to trigger growth arrest upon sensing a phage-encoded protein (Ocr). Interestingly, the Ocr protein has been found to inhibit R-M systems and BREX systems, making PARIS a suitable defense mechanism against RM resistant and/or BREX resistant phages :ref{doi=0.1016/j.chom.2022.02.018,10.1093/nar/gkaa510,10.1007/BF01036001}. ## Example of genomic structure -- GitLab