From fb30ed4e670388cd0c3c18de9cfed932cb9d9bb2 Mon Sep 17 00:00:00 2001
From: tclabby <tyler.clabby@pasteur.fr>
Date: Fri, 21 Mar 2025 13:54:08 +0100
Subject: [PATCH] Update cbass.md
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# CBASS
+## Description
+
+The CBASS system stands for cyclic oligonucleotide-based antiphage signaling systems :ref{doi=10.1016/j.molcel.2021.10.020}. There are four types and multiple subtypes of characterized CBASS trans membrane systems. Activation of this system results in cell death to prevent phage replication. This system has a shared ancestry with the cGAS-STING innate immune pathway in animals :ref{doi=10.1038/s41564-020-0777-y}
+## Molecular mechanism
+
+CBASS effector proteins limit phage propagation through membrane disruption. When CBASS is activated, Cap15 spreads throughout the cell and causes the inner membrane to rupture :ref{doi=10.1016/j.molcel.2021.10.020}
## Example of genomic structure
A total of 4 subsystems have been described for the CBASS system.
--
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