From fc275ee53c661cd63d96205616dd41edb829f974 Mon Sep 17 00:00:00 2001 From: aherrero <alba.herrero-del-valle@pasteur.fr> Date: Fri, 24 Nov 2023 18:13:18 +0100 Subject: [PATCH] Update sanata.md --- content/3.defense-systems/sanata.md | 22 ++++++++++++++-------- 1 file changed, 14 insertions(+), 8 deletions(-) diff --git a/content/3.defense-systems/sanata.md b/content/3.defense-systems/sanata.md index 1a7f6d2f..5fc9a496 100644 --- a/content/3.defense-systems/sanata.md +++ b/content/3.defense-systems/sanata.md @@ -10,9 +10,23 @@ tableColumns: Activator: Unknown Effector: Unknown PFAM: PF08843 +contributors: + - Alba Herrero del Valle + +relevantAbstracts: + - doi: 10.1016/j.molcel.2013.02.002 --- # SanaTA + +## Description + +The SanaTA system is composed of 2 proteins: SanaT and, SanaA, where SanaT encodes a toxin and SanaA encodes an antitoxin to form a toxin-antitoxin (TA) system. The toxin protein, SanaT, contains a Nucleotidyl transferase domain (PF08843). This system provides resistance against mutated T7 phages that lack the nonessential 4.5 gene in *Shewanella sp.* ANA-3. Sberro et al. showed that the defensiveness of sanaTA depends on the cleavage of SanaA by the Lon system, a protease that degrades the antitoxin to allow the activity of the toxin :ref{doi=10.1016/j.molcel.2013.02.002}. + +## Molecular mechanism + +It has been shown to function as a toxin-antitoxin (TA) system. + ## Example of genomic structure The SanaTA system is composed of 2 proteins: SanaT and, SanaA. @@ -75,13 +89,5 @@ end style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none </mermaid> -## Relevant abstracts - -::relevant-abstracts ---- -items: - - doi: 10.1016/j.molcel.2013.02.002 ---- -:: -- GitLab