diff --git a/simulation/README.md b/simulation/README.md
index 1959af1caeb06fb3a03a9b224ec23e140ff2b34b..bf1e91848ff38493b5a05a9780f80ef668784ae4 100644
--- a/simulation/README.md
+++ b/simulation/README.md
@@ -1,17 +1,18 @@
 # Simulation
 
-[CAMISIM](https://github.com/CAMI-challenge/CAMISIM) can model different microbial abundance
-profiles (from multi-sample time series to differential abundance studies) and was used to
-generate the benchmark data sets of the first CAMI challenge.
+[InSilicoSeq](https://github.com/HadrienG/InSilicoSeq) is a sequencing simulator producing
+realistic Illumina reads. Primarily intended for simulating metagenomic samples, it can also
+be used to produce sequencing data from a single genome.
 
-We describe here only the usage of de novo metagenomes simulation. For a more exhaustive
-documentation, please refer to [CASISIM wiki](https://github.com/CAMI-challenge/CAMISIM/wiki).
+We describe here only the usage for a simple simulation. For a more exhaustive documentation,
+please refer to [InSilicoSeq documentation](https://insilicoseq.readthedocs.io/en/latest/?badge=latest).
 
 ## Install
 
-CAMISIM contains a lot of dependencies and the list can be found [Here](https://github.com/CAMI-challenge/CAMISIM/wiki/User-manual#installation).
+You have several ways of installing InSilico seq that can be found [Here](https://insilicoseq.readthedocs.io/en/latest/iss/install.html).
 
-However, we recommand the use of the docker image `cami/camisim:latest` or the singularity one ([here](https://gitlab.pasteur.fr/metagenomics/singularity/tree/master/tools/camisim), only from docker for the moment).
+Here, we will use of the docker image `hadrieng/insilicoseq:1.4.2` or the singularity one
+([here]) built from the docker image.
 
 ## Run de novo metagenomes simulation