diff --git a/client/pages/index.vue b/client/pages/index.vue index 08eb5cf2a94c073710079cbc4267cdf4c692ecc7..787c76abcdc07306af8398735abd376d72cf4651 100644 --- a/client/pages/index.vue +++ b/client/pages/index.vue @@ -5,11 +5,15 @@ <v-row> <v-col cols="12" sm="10" offset-sm="1"> <v-card-text class="main-intro"> - The JASS web interface efficiently compute multi-trait genome-wide association study (GWAS) and enable user to interactively explore results. - Multi-trait GWAS can increase statistical power by leveraging pleiotropy, but also can deepen our understanding of SNPs functional effect (for a detailed explanation see the citation box below). - Currently this website host a total of <b>{{ getTotalPhenotypes.toLocaleString() }}</b> phenotypes available from <b>{{ getTotalTables.toLocaleString() }}</b> ancestries for analysis with the Omnibus test. - All GWAS have been pre-processed using the <a href="https://gitlab.pasteur.fr/statistical-genetics/jass_suite_pipeline">JASS pre-processing pipeline</a> and imputation of missing statistics has been conducted using the <a href="https://gitlab.pasteur.fr/statistical-genetics/raiss">RAISS software</a>, resulting in a total of <b>{{ getTotalSNP.toLocaleString() }}</b> SNPs available for analysis. - To analyze data in your own facility and/or access supplementary joint analysis tests, please download and install the <a href="https://statistical-genetics.pages.pasteur.fr/jass/">JASS python package.</a> + During the past decade, the statistical genetic community discovered and replicated thousands of variant-trait associations in human populations. However, the sample size required to detect additional variants using standard univariate association screening is increasingly prohibitive. Multi-trait GWAS offers a relevant alternative: it can improve statistical power and lead to new insights about gene function and the joint genetic architecture of human phenotypes. + </v-card-text> + + <v-card-text class="main-intro"> + In practice, conducting multi-trait GWAS can become a hurdle due to missing values, heterogeneous data format, and computational cost. JASS (Joint Analysis of Summary Statistics) webserver solves all these practical barriers allowing investigators to conduct multi-trait GWAS interactively. Through this website, you can investigate <b>{{ getTotalPhenotypes.toLocaleString() }}</b> traits spanning several clinical domains and <b>{{ getTotalTables.toLocaleString() }}</b> ancestries. The results page displays genetic correlation matrices between traits, downloadable Manhattan plots and new associations table. + </v-card-text> + + <v-card-text class="main-intro"> + Our databases have been curated and imputed using the python package <a href="https://gitlab.pasteur.fr/statistical-genetics/jass_preprocessing">JASS preprocessing</a> (data QC and harmonization) and <a href="https://gitlab.pasteur.fr/statistical-genetics/raiss">RAISS</a> (imputation of summary statistics). To conduct multi-trait GWAS on your own data refers to the <a href="https://statistical-genetics.pages.pasteur.fr/jass/">JASS python package documentation</a>. A Nextflow pipeline encapsulating summary statistic curation, imputation, and multi-trait GWAS is available <a href="https://gitlab.pasteur.fr/statistical-genetics/jass_suite_pipeline">here</a>. </v-card-text> </v-col> </v-row>