Skip to content
Snippets Groups Projects

Rewriting history of defense systems

Closed Jean c requested to merge jeanrjc1-main-patch-48377 into main
1 file
+ 2
0
Compare changes
  • Side-by-side
  • Inline
+ 2
0
@@ -11,6 +11,8 @@ In response to this evolutionary pressure, bacteria have developed an arsenal of
## History
I re-wrote the history ! Sure ?
The first anti-phage defense system was discovered in the early 1950s by two separate teams of researchers (Luria and Human, 1952 ; Bertani and Wiegle 1952). Luria and Human reported a mysterious phenomenon, where one phage was only capable of infecting a specific bacterial strain once. The progeny phages produced by this first round of infection had lost their ability to infect the same strain again, yet remained able to infect other bacterial strains. For them, this could only mean that "the genotype of the host in which a virus reproduces affects the phenotype of the new virus" (Luria and Human, 1952). A similar phenomenon was shortly after described by Bertani and Wiegle.
Their work was in fact the first report of what would later be named Restriction-Modification ([RM](/defense-systems/rm)) system, which is considered to be the first anti-phage defense system discovered.
Loading