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@@ -10,9 +10,29 @@ tableColumns:
Activator: Unknown
Effector: Unknown
PFAM: PF00176, PF00271, PF04545, PF04851, PF13091
contributors:
- Florian Tesson
relevantAbstracts:
- doi: 10.1023/A:1002027321171
- doi: 10.1016/j.mib.2005.06.006
- doi: 10.1128/aem.66.6.2647-2651.2000
---
# AbiR
## Description
AbiR is a defense system discovered in 2000 :ref{doi=10.1128/aem.66.6.2647-2651.2000}.
AbiR is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry :ref{doi=10.1016/j.mib.2005.06.006}. AbiR is classified as abortive infection in :ref{doi=10.1016/j.mib.2023.102312}.
AbiR is composed of 3 genes: AbiRa, AbiRb, AbiRc.
AbiRa encodes a sigma70 RNA polymerase subunit. AbiRb as homology with ParB nuclease domain according to HHpred.
AbiRc has two different domains: a N_terminal PLD domain (PF13091) and at the C term an SNF2 DNA dependant ATPase.
## Molecular mechanism
As far as we are aware, the molecular mechanism is unknown.
## Example of genomic structure
The AbiR is composed of 3 proteins: AbiRa, AbiRb and AbiRc.
@@ -34,32 +54,24 @@ The system was detected in 28 different species.
Proportion of genome encoding the AbiR system for the 14 phyla with more than 50 genomes in the RefSeq database.
## Structure
## Structure
### AbiR
##### Example 1
::molstar-pdbe-plugin
---
height: 700
dataUrl: /abir/AbiR,AbiR__AbiRa,0,V-plddts_88.45598.pdb
---
::
dataUrls:
- /abir/AbiR.AbiR__AbiRc.0.V.cif
- /abir/AbiR.AbiR__AbiRb.0.V.cif
- /abir/AbiR.AbiR__AbiRa.0.V.cif
::molstar-pdbe-plugin
---
height: 700
dataUrl: /abir/AbiR,AbiR__AbiRb,0,V-plddts_92.82829.pdb
---
::
::molstar-pdbe-plugin
---
height: 700
dataUrl: /abir/AbiR,AbiR__AbiRc,0,V-plddts_86.60767.pdb
---
::
## Experimental validation
<mermaid>
graph LR;
Chopin_2005[<a href='https://doi.org/10.1016/j.mib.2005.06.006'>Chopin et al., 2005</a>] --> Origin_0
@@ -84,14 +96,4 @@ end
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
## Relevant abstracts
::relevant-abstracts
---
items:
- doi: 10.1023/A:1002027321171
- doi: 10.1016/j.mib.2005.06.006
---
::