Skip to content
Snippets Groups Projects

Update cbass.md

Open tclabby requested to merge tclabby-main-patch-29326 into main
1 file
+ 6
0
Compare changes
  • Side-by-side
  • Inline
@@ -20,6 +20,12 @@ relevantAbstracts:
---
# CBASS
## Description
The CBASS system stands for cyclic oligonucleotide-based antiphage signaling systems <a href=https://doi.org/10.1016/j.molcel.2021.10.020 a>. There are four types and multiple subtypes of characterized CBASS trans membrane systems. Activation of this system results in cell death to prevent phage replication. This system has a shared ancestry with the cGAS-STING innate immune pathway in animals <a href= https://doi.org/10.1038/s41564-020-0777-y>
## Molecular mechanism
CBASS effector proteins limit phage propagation through membrane disruption. When CBASS is activated, Cap15 spreads throughout the cell and causes the inner membrane to rupture <a href=https://doi.org/10.1016/j.molcel.2021.10.020>
## Example of genomic structure
A total of 4 subsystems have been described for the CBASS system.