pd-t7-1.md

title: PD-T7-1
layout: article
tableColumns:
    article:
      doi: 10.1038/s41564-022-01219-4
      abstract: |
        The ancient, ongoing coevolutionary battle between bacteria and their viruses, bacteriophages, has given rise to sophisticated immune systems including restriction-modification and CRISPR-Cas. Many additional anti-phage systems have been identified using computational approaches based on genomic co-location within defence islands, but these screens may not be exhaustive. Here we developed an experimental selection scheme agnostic to genomic context to identify defence systems in 71 diverse E. coli strains. Our results unveil 21 conserved defence systems, none of which were previously detected as enriched in defence islands. Additionally, our work indicates that intact prophages and mobile genetic elements are primary reservoirs and distributors of defence systems in E. coli, with defence systems typically carried in specific locations or hotspots. These hotspots encode dozens of additional uncharacterized defence system candidates. Our findings reveal an extended landscape of antiviral immunity in E. coli and provide an approach for mapping defence systems in other species.
    Sensor: Unknown
    Activator: Unknown
    Effector: Unknown

PD-T7-1

Example of genomic structure

The PD-T7-1 is composed of 1 protein: PD-T7-1.

Here is an example found in the RefSeq database:

The PD-T7-1 system in Klebsiella sp. P1927 (GCF_018204675.1, NZ_CP073377) is composed of 1 protein: PD-T7-1 (WP_004150873.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the PD-T7-1 is detected in 748 genomes (3.28 %).

The system was detected in 146 different species.

Proportion of genome encoding the PD-T7-1 system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

PD-T7-1

::molstar-pdbe-plugin

height: 700 dataUrl: /pd-t7-1/PD-T7-1__PD-T7-1-plddts_93.91174.pdb

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Experimental validation

graph LR; Vassallo_2022[Vassallo et al., 2022] --> Origin_0 Origin_0[Escherichia coli RCQ85672.1] --> Expressed_0[Escherichia coli] Expressed_0[Escherichia coli] ----> T7 subgraph Title1[Reference] Vassallo_2022 end subgraph Title2[System origin] Origin_0 end subgraph Title3[Expression species] Expressed_0 end subgraph Title4[Phage infected] T7 end style Title1 fill:none,stroke:none,stroke-width:none style Title2 fill:none,stroke:none,stroke-width:none style Title3 fill:none,stroke:none,stroke-width:none style Title4 fill:none,stroke:none,stroke-width:none ## Relevant abstracts

::relevant-abstracts

items: - doi: 10.1038/s41564-022-01219-4

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