gao_tery.md 3.13 KiB
title: Gao_TerY
layout: article
tableColumns:
article:
doi: 10.1126/science.aba0372
abstract: |
Bacteria and archaea are frequently attacked by viruses and other mobile genetic elements and rely on dedicated antiviral defense systems, such as restriction endonucleases and CRISPR, to survive. The enormous diversity of viruses suggests that more types of defense systems exist than are currently known. By systematic defense gene prediction and heterologous reconstitution, here we discover 29 widespread antiviral gene cassettes, collectively present in 32% of all sequenced bacterial and archaeal genomes, that mediate protection against specific bacteriophages. These systems incorporate enzymatic activities not previously implicated in antiviral defense, including RNA editing and retron satellite DNA synthesis. In addition, we computationally predict a diverse set of other putative defense genes that remain to be characterized. These results highlight an immense array of molecular functions that microbes use against viruses.
Sensor: Unknown
Activator: Unknown
Effector: Unknown
relevantAbstracts:
- doi: 10.1126/science.aba0372Gao_TerY
Example of genomic structure
The Gao_TerY is composed of 3 proteins: TerYA, TerYB and TerYC.
Here is an example found in the RefSeq database:
The Gao_TerY system in Arachidicoccus terrestris (GCF_020042345.1, NZ_CP083387) is composed of 3 proteins TerYA (WP_224070248.1) TerYB (WP_224070249.1) TerYC (WP_224070250.1)
Distribution of the system among prokaryotes
Among the 22,803 complete genomes of RefSeq, the Gao_TerY is detected in 126 genomes (0.55 %).
The system was detected in 74 different species.
Proportion of genome encoding the Gao_TerY system for the 14 phyla with more than 50 genomes in the RefSeq database.
Structure
Gao_TerY
Example 1
::molstar-pdbe-plugin
height: 700 dataUrls:
- /gao_tery/Gao_TerY.Gao_TerY__TerYA.0.V.cif
- /gao_tery/Gao_TerY.Gao_TerY__TerYB.0.V.cif
- /gao_tery/Gao_TerY.Gao_TerY__TerYC.0.V.cif
::