abia.md

title: AbiA
tableColumns:
    article:
      doi: 10.1016/j.mib.2005.06.006
      abstract: |
        Abortive infection (Abi) systems, also called phage exclusion, block phage multiplication and cause premature bacterial cell death upon phage infection. This decreases the number of progeny particles and limits their spread to other cells allowing the bacterial population to survive. Twenty Abi systems have been isolated in Lactococcus lactis, a bacterium used in cheese-making fermentation processes, where phage attacks are of economical importance. Recent insights in their expression and mode of action indicate that, behind diverse phenotypic and molecular effects, lactococcal Abis share common traits with the well-studied Escherichia coli systems Lit and Prr. Abis are widespread in bacteria, and recent analysis indicates that Abis might have additional roles other than conferring phage resistance.

The AbiA system have been describe in a total of 2 subsystems.

Here is some example found in the RefSeq database:

AbiA_large subsystem in the genome of Lactobacillus amylovorus (GCF_002706375.1) is composed of 1 protein: AbiA_large (WP_056940268.1).

AbiA_small subsystem in the genome of Mesobacillus foraminis (GCF_003667765.1) is composed of 2 proteins: AbiA_small (WP_121614402.1)and, AbiA_SLATT (WP_121614403.1).

Distribution of the system among prokaryotes

The AbiA system is present in a total of 35 different species.

Among the 22k complete genomes of RefSeq, this system is present in 50 genomes (0.2 %).

Proportion of genome encoding the AbiA system for the 14 phyla with more than 50 genomes in the RefSeq database. Pie chart of the repartition of all the subsystems found in the RefSeq database.

Experimental validation

AbiA systems were experimentally validated using:

A system from lactococcal plasmid in lactococci has an anti-phage effect against 936, c2, P335 (Chopin et al., 2005)

Relevant abstracts

::article-doi-list

items: - doi: 10.1023/A:1002027321171 title: Bacteriophage defence systems in lactic acid bacteria - doi: 10.1016/j.mib.2005.06.006 abstract: | Abortive infection (Abi) systems, also called phage exclusion, block phage multiplication and cause premature bacterial cell death upon phage infection. This decreases the number of progeny particles and limits their spread to other cells allowing the bacterial population to survive. Twenty Abi systems have been isolated in Lactococcus lactis, a bacterium used in cheese-making fermentation processes, where phage attacks are of economical importance. Recent insights in their expression and mode of action indicate that, behind diverse phenotypic and molecular effects, lactococcal Abis share common traits with the well-studied Escherichia coli systems Lit and Prr. Abis are widespread in bacteria, and recent analysis indicates that Abis might have additional roles other than conferring phage resistance. - doi: 10.1093/nar/gkac467

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