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Commit 1ecf72e8 authored by fltesson's avatar fltesson
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add exp validation + structure form AbiD

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...@@ -20,7 +20,7 @@ relevantAbstracts: ...@@ -20,7 +20,7 @@ relevantAbstracts:
## Description ## Description
The Abi2 system corresponds to a group of abortive infection system: [AbiD](/defense-systems/abid), AbiD1 and AbiF. The Abi2 system corresponds to a group of abortive infection systems: [AbiD](/defense-systems/abid), AbiD1 and AbiF.
The Abi2/AbiD1 system of lactococci is composed of a single protein Abi_2 :ref{doi=10.1016/j.mib.2005.06.006}. Expression of the protein is toxic to the bacteria and is therefore highly regulated. Expression of the protein is triggered by the orf1 of phage bIL66 which results in inhibition of the phage RuvC-like endonuclease activity and stops phage multiplication. The Abi2/AbiD1 system of lactococci is composed of a single protein Abi_2 :ref{doi=10.1016/j.mib.2005.06.006}. Expression of the protein is toxic to the bacteria and is therefore highly regulated. Expression of the protein is triggered by the orf1 of phage bIL66 which results in inhibition of the phage RuvC-like endonuclease activity and stops phage multiplication.
...@@ -54,5 +54,46 @@ Proportion of genome encoding the Abi2 system for the 14 phyla with more than 50 ...@@ -54,5 +54,46 @@ Proportion of genome encoding the Abi2 system for the 14 phyla with more than 50
## Structure ## Structure
### Abi2/AbiD
##### Example 1
::molstar-pdbe-plugin
---
height: 700
dataUrls:
- /abid/AbiD__AbiD.cif
---
::
## Experimental validation ## Experimental validation
As Abi2 is a group of different Abortive infection systems, here is the experimental validation of AbiD:
<mermaid>
graph LR;
Chopin_2005[<a href='https://doi.org/10.1016/j.mib.2005.06.006'>Chopin et al., 2005</a>] --> Origin_0
Origin_0[lactococcal plasmid
<a href='https://ncbi.nlm.nih.gov/protein/AAA63619.1'>AAA63619.1</a>] --> Expressed_0[lactococci]
Expressed_0[lactococci] ----> 936 & c2 & P335
subgraph Title1[Reference]
Chopin_2005
end
subgraph Title2[System origin]
Origin_0
end
subgraph Title3[Expression species]
Expressed_0
end
subgraph Title4[Phage infected]
936
c2
P335
end
style Title1 fill:none,stroke:none,stroke-width:none
style Title2 fill:none,stroke:none,stroke-width:none
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
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