Merge branch 'hshomar-main-patch-19481' into 'main'

Update drt.md

See merge request !102

content/3.defense-systems/drt.md

@@ -10,9 +10,37 @@ tableColumns:
     Activator: Unknown
     Effector: Unknown
     PFAM: PF00078
+contributors: 
+  - Helena Shomar
+  - Marie Guillaume
+relevantAbstracts:
+  - doi: 10.1093/nar/gkac467
+  - doi: 10.1126/science.aba0372
 ---
 
 # DRT
+
+## Description
+DRT stands for Defense-associated Reverse Transcriptases.
+DRTs are a widespread and highly diverse family of defense systems, characterized by reverse transcriptase (RTs) components with antiphage properties. These RTs belong to the so-called group of unknown RTs (UG) and are closely related to the Abortive Infection system (Abi) RTs.
+
+DRT systems were experimentally validated in _Escherichia coli_ and demonstrated to be effective against an array of diverse phages.
+So far, DRTs have been classified in 9 different types. Essential components of each DRT type are:
+- DRT Type 1:   UG1  (RT-nitrilaseTM domains)
+- DRT Type 2:   UG2  (RT domain)
+- DRT Type 3:   UG3  (RT domain), UG8 (RT domain) and ncRNA
+- DRT Type 4:   UG15 (RT-alphaRep domains)
+- DRT Type 5:   UG16 (RT domain)
+- DRT Type 6:   UG12 (RT-alphaRep domains)
+- DRT Type 7:   UG10 (PrimS-RT-alphaRep domains)
+- DRT Type 8:   UG7  (RT-alphaRep-PDDExK domains)
+- DRT Type 9:   UG28 (RT-alphaRep domains) and ncRNA
+
+
+## Molecular mechanism
+To our knowledge, the molecular mechanism is unknown. 
+Similarly, for the other systems of this family, the molecular mechanism remain unknown. 
+
 ## Example of genomic structure
 
 A total of 9 subsystems have been described for the DRT system.
@@ -187,7 +215,7 @@ Escherichia coli
     Origin_3[ RT UG15 Type 4
 Escherichia coli 
 <a href='https://ncbi.nlm.nih.gov/protein/GCK53192.1'>GCK53192.1</a>] --> Expressed_3[Escherichia coli]
-    Expressed_3[Escherichia coli] ----> T5 & T3 & T7 & Phi-V1 & ZL19
+    Expressed_3[Escherichia coli] ----> T5 & T3 & T7 & Phi-V1 & ZL-19
     Gao_2020[<a href='https://doi.org/10.1126/science.aba0372'>Gao et al., 2020</a>] --> Origin_4
     Origin_4[ RT UG16 Type 5
 Escherichia coli  
@@ -251,12 +279,12 @@ end
         T3
         T7
         Phi-V1
-        ZL19
+        ZL-19
         T5
         T3
         T7
         Phi-V1
-        ZL19
+        ZL-19
         T2
         T2
         T5
@@ -272,14 +300,5 @@ end
     style Title3 fill:none,stroke:none,stroke-width:none
     style Title4 fill:none,stroke:none,stroke-width:none
 </mermaid>
-## Relevant abstracts
-
-::relevant-abstracts
----
-items:
-    - doi: 10.1093/nar/gkac467
-    - doi: 10.1126/science.aba0372
 
----
-::