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Commit 232f9637 authored by hgeorjon's avatar hgeorjon
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Renamed the page from FS-SMA to SMA. Corrected the structure of the SMA page,...

Renamed the page from FS-SMA to SMA. Corrected the structure of the SMA page, created the Description and Molecular mechanism sections. 
/!\ Missing sections:
- Example of genomic structure
- Distribution of the system among prokaryotes
- Experimental validation: Syntax error in text
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title: FS_Sma title: SMA
layout: article layout: article
tableColumns: tableColumns:
article: article:
...@@ -7,11 +7,26 @@ tableColumns: ...@@ -7,11 +7,26 @@ tableColumns:
abstract: | abstract: |
Bacteria encode sophisticated anti-phage systems that are diverse and versatile and display high genetic mobility. How this variability and mobility occurs remains largely unknown. Here, we demonstrate that a widespread family of pathogenicity islands, the phage-inducible chromosomal islands (PICIs), carry an impressive arsenal of defense mechanisms, which can be disseminated intra- and inter-generically by helper phages. These defense systems provide broad immunity, blocking not only phage reproduction, but also plasmid and non-cognate PICI transfer. Our results demonstrate that phages can mobilize PICI-encoded immunity systems to use them against other mobile genetic elements, which compete with the phages for the same bacterial hosts. Therefore, despite the cost, mobilization of PICIs may be beneficial for phages, PICIs, and bacteria in nature. Our results suggest that PICIs are important players controlling horizontal gene transfer and that PICIs and phages establish mutualistic interactions that drive bacterial ecology and evolution. Bacteria encode sophisticated anti-phage systems that are diverse and versatile and display high genetic mobility. How this variability and mobility occurs remains largely unknown. Here, we demonstrate that a widespread family of pathogenicity islands, the phage-inducible chromosomal islands (PICIs), carry an impressive arsenal of defense mechanisms, which can be disseminated intra- and inter-generically by helper phages. These defense systems provide broad immunity, blocking not only phage reproduction, but also plasmid and non-cognate PICI transfer. Our results demonstrate that phages can mobilize PICI-encoded immunity systems to use them against other mobile genetic elements, which compete with the phages for the same bacterial hosts. Therefore, despite the cost, mobilization of PICIs may be beneficial for phages, PICIs, and bacteria in nature. Our results suggest that PICIs are important players controlling horizontal gene transfer and that PICIs and phages establish mutualistic interactions that drive bacterial ecology and evolution.
PFAM: PF02452 PFAM: PF02452
contributors:
- Héloïse Georjon
relevantAbstracts:
- doi: 10.1016/j.cell.2022.07.014
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# FS_Sma # SMA
## Description
SMA (single-protein MazF-like antiphage system) was identified in a phage-inducible chromosomal island (PICI) found in *Staphylococcus aureus* ref{doi=10.1016/j.cell.2022.07.014}. SMA was shown to inhibit phage infection and to inhibit the formation of new virions after prophage induction.
## Molecular mechanisms
The SMA protein comprises a domain analogous to MazF. MazF a protein that is normally part of the MazEF toxin-antitoxin systems, in which MazF is a toxic endoribonuclease that targets mRNA ref{10.1016/s1097-2765(03)00402-7}.
As far as we are aware, the precise molecular mechanism of SMA is unknown.
## Example of genomic structure
## Distribution of the system among prokaryotes
## To do
## Structure ## Structure
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## Relevant abstract
::relevant-abstracts
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items:
- doi: 10.1016/j.cell.2022.07.014
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::
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