The Butters_gp57r system is encoded in the Butters mycobacterium prophage and has been shown to inhibit rival phage replication <ahref='https://ncbi.nlm.nih.gov/protein/YP_009304936.1'>.
## Molecular Mechanism
Butters_gp57r is activated post-DNA injeciton and inhibits island3 and other phage DNA amplification. This system may inhibit heterotypic phage infeciton with the HEPN domain <ahref='https://ncbi.nlm.nih.gov/protein/YP_009304936.1'>.