Update abiu.md

content/3.defense-systems/abiu.md

@@ -3,16 +3,29 @@ title: AbiU
 layout: article
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     article:
-      doi: 10.1016/j.mib.2005.06.006
+      doi: 10.1128/AEM.67.11.5225-5232.2001
       abstract: |
-        Abortive infection (Abi) systems, also called phage exclusion, block phage multiplication and cause premature bacterial cell death upon phage infection. This decreases the number of progeny particles and limits their spread to other cells allowing the bacterial population to survive. Twenty Abi systems have been isolated in Lactococcus lactis, a bacterium used in cheese-making fermentation processes, where phage attacks are of economical importance. Recent insights in their expression and mode of action indicate that, behind diverse phenotypic and molecular effects, lactococcal Abis share common traits with the well-studied Escherichia coli systems Lit and Prr. Abis are widespread in bacteria, and recent analysis indicates that Abis might have additional roles other than conferring phage resistance.
+        This study reports on the identification and characterization of a novel abortive infection system, AbiU, from Lactococcus lactis. AbiU confers resistance to phages from the three main industrially relevant lactococcal phage species: c2, 936, and P335. The presence of AbiU reduced the efficiency of plaquing against specific phage from each species as follows: 3.7 × 10−1, 1.0 × 10−2, and 1.0 × 10−1, respectively. abiU involves two open reading frames,abiU1 (1,772 bp) and abiU2 (1,019 bp). Evidence indicates that AbiU1 is responsible for phage resistance and that AbiU2 may downregulate phage resistance against 936 and P335 type phages but not c2 type phage. AbiU appeared to delay transcription of both phage 712 and c2, with the effect being more marked on phage c2.
     Sensor: Unknown
     Activator: Unknown
     Effector: Unknown
     PFAM: PF10592
+contributor: 
+    - Nathalie Bechon
+relevant-abstracts
+    - doi: 10.1023/A:1002027321171
+    - doi: 10.1016/j.mib.2005.06.006
+    - doi: 10.1128/AEM.67.11.5225-5232.2001
 ---
 
 # AbiU
+
+## Description
+AbiU is a single-protein abortive infection defense system described in *Lactococcus*. 
+
+## Molecular mechanism
+The molecular mechanism of AbiU is not well understood. It was shown that cells expressing AbiU showed delayed transcription of phage DNA, although how it is achieved, or how does it protect the bacterial culture is not understood. AbiU was shown to be encoded near another gene that seems to be an inhibitor of defense :ref{doi=10.1128/AEM.67.11.5225-5232.2001}.
+
 ## Example of genomic structure
 
 The AbiU system is composed of one protein: AbiU.
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-## Relevant abstracts
-
-::relevant-abstracts
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-items:
-    - doi: 10.1023/A:1002027321171
-    - doi: 10.1016/j.mib.2005.06.006
-
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-::
-