Merge branch 'aherrero-main-patch-96166' into 'main'

Update eleos.md

See merge request !84

content/3.defense-systems/eleos.md

@@ -10,16 +10,26 @@ tableColumns:
     Activator: Unknown
     Effector: Unknown
     PFAM: PF00350, PF01926, PF18709
+contributors: 
+    - Alba Herrero del Valle
 relevantAbstracts:
     - doi: 10.1016/j.chom.2022.09.017
+    - doi: 10.1101/2022.12.12.520048
 ---
 
 # Eleos
-The Eleos system was previously described as the Dynamins-like system in (Millman et al, 2022).
+
+## Description
+
+\The Eleos (for the greek goddess of mercy) system was previously described as the Dynamins-like system in :ref{doi=10.1016/j.chom.2022.09.017}. It is formed by the LeoA and LeoBC proteins. LeoBC has been found to be analogous to GIMAPs (GTPases immunity-associated proteins), that are interferon inducible :ref{doi=10.1101/2022.12.12.520048}. LeoA in *E. coli* ETEC H10407 localises to the periplasm and has been suggested to potientiate bacterial virulence. Its crystal structure has been solved :ref{doi=10.1371/journal.pone.0107211}. Eleos from *Bacillus vietnamensis* NBRC 101237 has been found to protect against jumbo-phages in *Bacillus subtilis* :ref{doi=10.1016/j.chom.2022.09.017}.
+
+## Molecular mechanism
+
+As far as we are aware, the molecular mechanism is unknown. 
 
 ## Example of genomic structure
 
-The Eleos is composed of 4 proteins: LeoA, LeoBC, LeoB and LeoC.
+The Eleos system is composed of 2 proteins: LeoA and, LeoBC. Sometimes, the system is in three genes: LeoA, LeoB and LeoC.
 
 Here is an example found in the RefSeq database:
 
@@ -40,6 +50,18 @@ Proportion of genome encoding the Eleos system for the 14 phyla with more than 5
 
 
 ## Structure
+### Experimentaly determined structure
+From :ref{doi=10.1371/journal.pone.0107211} in *Escherichia coli* (ETEC) strain H10407:
+
+::molstar-pdbe-plugin
+---
+height: 700
+dataUrl: /eleos/4aur_LeoA_1mer.pdb
+---
+::
+
+
+
 ### Eleos
 ##### Example 1
 
@@ -79,4 +101,3 @@ end
     style Title3 fill:none,stroke:none,stroke-width:none
     style Title4 fill:none,stroke:none,stroke-width:none
 </mermaid>
-