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Effector: Degrading nucleic acids
PFAM: PF00580, PF11398, PF13175, PF13245, PF13304, PF13361, PF13476
contributors:
- Nathalie Bechon
- Nathalie Bechon
relevantAbstracts:
- doi: 10.1093/nar/gkab277
- doi: 10.1126/science.aar4120
- doi: 10.1016/j.chom.2023.06.014
- doi: 10.1101/2023.05.01.538945
- doi: 10.1101/2023.05.01.538930
- doi: 10.1093/nar/gkab277
- doi: 10.1126/science.aar4120
- doi: 10.1016/j.chom.2023.06.014
- doi: 10.1101/2023.05.01.538945
- doi: 10.1101/2023.05.01.538930
---
# Gabija
## Description
Gabija is named after the Lithuanian spirit of fire, protector of home and family. It is a two gene defense system found in 8.5% of the 4360 bacterial and archeal genomes that were initially analyzed :ref{doi=10.1126/science.aar4120}. Both proteins are necessary for defense and are forming a heteromeric octamer complex: GajA forms a central tetramer surrounded by two GajB dimers ref:{doi=10.1101/2023.05.01.538945, 10.1093/nar/gkad951}. A phage protein inhibiting Gabija function was described, Gabidja anti defense 1 (Gad1) :ref{doi=10.1101/2023.05.01.538945, 10.1101/2023.05.01.538930}.
Gabija is named after the Lithuanian spirit of fire, protector of home and family. It is a two gene defense system found in 8.5% of the 4360 bacterial and archeal genomes that were initially analyzed :ref{doi=10.1126/science.aar4120}. Both proteins are necessary for defense and are forming a heteromeric octamer complex: GajA forms a central tetramer surrounded by two GajB dimers ref:{doi=10.1101/2023.05.01.538945,10.1093/nar/gkad951}. A phage protein inhibiting Gabija function was described, Gabidja anti defense 1 (Gad1) :ref{doi=10.1101/2023.05.01.538945,10.1101/2023.05.01.538930}.
## Molecular mechanism
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