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Activator: Unknown
Effector: Unknown
PFAM: PF08843
contributors:
- Alba Herrero del Valle
relevantAbstracts:
- doi: 10.1016/j.molcel.2013.02.002
---
# SanaTA
## Description
The SanaTA system is composed of 2 proteins: SanaT and, SanaA, where SanaT encodes a toxin and SanaA encodes an antitoxin to form a toxin-antitoxin (TA) system. The toxin protein, SanaT, contains a Nucleotidyl transferase domain (PF08843). This system provides resistance against mutated T7 phages that lack the nonessential 4.5 gene in *Shewanella sp.* ANA-3. Sberro et al. showed that the defensiveness of sanaTA depends on the cleavage of SanaA by the Lon system, a protease that degrades the antitoxin to allow the activity of the toxin :ref{doi=10.1016/j.molcel.2013.02.002}.
## Molecular mechanism
It has been shown to function as a toxin-antitoxin (TA) system.
## Example of genomic structure
The SanaTA system is composed of 2 proteins: SanaT and, SanaA.
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style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
## Relevant abstracts
::relevant-abstracts
---
items:
- doi: 10.1016/j.molcel.2013.02.002
---
::
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