Update abiq.md

add description mechanism and experimentaly validated structure #192 (closed)

content/3.defense-systems/abiq.md

@@ -10,13 +10,33 @@ tableColumns:
     Activator: Unknown
     Effector: Unknown
     PFAM: PF13958
+contributors: 
+  - Florian Tesson
 relevantAbstracts:
     - doi: 10.1023/A:1002027321171
     - doi: 10.1016/j.mib.2005.06.006
     - doi: 10.1128/AEM.64.12.4748-4756.1998
+    - doi: 10.1111/mmi.12129
 ---
 
 # AbiQ
+
+## Description
+
+AbiQ was discovered in 1998 on *Lactococcus lactis* plasmid :ref{doi=10.1128/AEM.64.12.4748-4756.1998}.
+
+AbiQ is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry :ref{doi=10.1016/j.mib.2005.06.006}. AbiQ is classified as abortive infection in :ref{doi=10.1016/j.mib.2023.102312}.
+
+AbiQ is composed of a single protein AbiQ and an RNA antitoxin (antiQ) :ref{doi=10.1111/mmi.12129}.
+
+## Molecular mechanism
+
+AbiQ act as an anti-toxin type III. AbiQ is an RNAase that will bind its antitoxin antiQ :ref{doi=10.1111/mmi.12129}.
+
+The AbiQ is constitutively expressed and bind to its antiQ RNA resulting in an inactivated AbiQ.
+To get activated, AbiQ needs the concentration of antiQ to decrease.
+However, during phage infection, the expression of the antiQ is constant and the authors do not know how the AbiQ is activated :ref{doi=10.1111/mmi.12129}.
+
 ## Example of genomic structure
 
 The AbiQ is composed of 1 protein: AbiQ.
@@ -38,6 +58,18 @@ The system was detected in 111 different species.
 Proportion of genome encoding the AbiQ system for the 14 phyla with more than 50 genomes in the RefSeq database.
 
 
+## Structure
+### Experimentally determined structure
+
+From :ref{doi=10.1111/mmi.12129} in *Lactococcus lactis*:
+
+::molstar-pdbe-plugin
+---
+height: 700
+dataUrl: /abiq/4glk_LlAbiQ_1mer.cif
+---
+::
+
 
 ## Structure
 ### AbiQ