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Merged Lucas PAOLI requested to merge lpaoli-main-patch-78102 into main
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Activator: Unknown
Activator: Unknown
Effector: Unknown
Effector: Unknown
PFAM: PF16162
PFAM: PF16162
 
contributors:
 
- Lucas Paoli
 
relevantAbstracts:
 
- doi: 10.1126/science.aar4120
 
- doi: 10.1101/2023.02.26.530102
---
---
# Kiwa
# Kiwa
 
 
## Description
 
 
The Kiwa antiviral defense system was first described in :ref{doi=10.1126/science.aar4120} and further described in :ref{doi=10.1101/2023.02.26.530102}. It is named after one of the divine guardians of the ocean in the Māori traditions. Kiwa is composed of two proteins: KwaA and KwaB.
 
## Molecular mechanisms
 
 
KwaA detects phage infection by detecting the inhibition of the host RNA polymerase by phages. This triggers the reponse by KwaB, which decreases phage DNA replication through a RecBCD-depdendent pathway :ref{doi=10.1101/2023.02.26.530102}.
 
## Example of genomic structure
## Example of genomic structure
The Kiwa system is composed of 2 proteins: KwaA and, KwaB.
The Kiwa system is composed of 2 proteins: KwaA and, KwaB.
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style Title3 fill:none,stroke:none,stroke-width:none
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
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## Relevant abstracts
::relevant-abstracts
---
items:
- doi: 10.1126/science.aar4120
---
::
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