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The Gao_upx system is composed by a single protein. It was predicted through a guilty by association approach independent of domain annotations and validated in a heterologous system :ref{doi=10.1126/science.aba0372}. It's been identified as part of a highly conserved core defense hotspot in *Pseudomonas aeruginosa* strains :ref{doi=10.1093/nar/gkad317}.
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