start working gaps6.md

content/3.defense-systems/gaps6.md

@@ -19,14 +19,22 @@ contributors :
 
 GAPS (GMT-encoded Anti-Phage System) antiphage systems were discovered on newly described Gamma-Mobile-Trio elements. 
 
-GAPS6 comprises two genes encoding WP_248387294.1 (GAPS6a) and WP_248387295.1 258 (GAPS6b) (Fig. 6a). These two proteins are encoded together in diverse Gram-negative 259 bacteria
+GAPS6 is composed of two proteins, [GAPS6a](https://www.ncbi.nlm.nih.gov/protein/WP_248387294.1/) and [GAPS6b](https://www.ncbi.nlm.nih.gov/protein/WP_248387295.1/). These two proteins are encoded together in diverse Gram-negative bacteria.
 
 ## Molecular mechanism
 
-Predicted structures in the original paper, show that GAPS4a and GAPS4b might interact and form a heterodimer. They suggest that GAPS4 binds to DNA. 
-GAPS4 is suggested to be an abortive infection system degrading host cell DNA upon phage infection.
+GAPS6b is essential for the defense phenotype, however it is not known whether GAPS6b could be sufficient.
+GAPS6b is composed of TPR repeats at the N-terminus, possibly allowing ligand binding and a predicted RNAse domain (PINc, PF08745.14) at the C-terminus. PINc domains have been implicated as toxins in bacterial toxin-antitoxin modules :ref{doi=10.1093/protein/gzq081}. The PINc domain is required for the anti-phage defense activity of GAPS6.
 
-## Structure
+## Example of genomic structure
+
+TODO
+
+## Distribution
+
+TODO
+
+## Predicted structure
 
 ### GAPS6
 
@@ -61,9 +69,7 @@ end
         Expressed_0
 end
     subgraph Title4[Phage infected]
-        T7
         T4
-        P1-vir
         Lambda-vir
 end
     style Title1 fill:none,stroke:none,stroke-width:none