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Merged Lucas PAOLI requested to merge lpaoli-dev-patch-80473 into dev
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@@ -10,12 +10,28 @@ tableColumns:
Activator: Unknown
Effector: Membrane disrupting (?)
PFAM: PF07693
contributors:
- Lucas Paoli
relevantAbstracts:
- doi: 10.1007/BF00327934
- doi: 10.1016/j.virol.2004.06.001
- doi: 10.1128/jb.173.20.6507-6514.1991
- doi: 10.1038/newbio231037a0
---
# Pif
## Description
The Pif system (Phage Inhibition by F factors) was first described by Morisson & Malamy :ref{doi=10.1038/newbio231037a0}. The Pif region of the F plasmid inhibits the phage T7 through abortive infection :ref{doi=10.1038/newbio231037a0,10.1007/BF00327934}.
## Molecular mechanisms
PifA was later identified as the effector of the abortive infection :ref{doi=10.1128/jb.173.20.6507-6514.1991,10.1016/j.virol.2004.06.001} through nucleotide depletion by increased membrane permeability (also known as "leakage").
## Example of genomic structure
The Pif system is composed of 2 proteins: PifC and, PifA.
The Pif system is composed of 2 proteins: PifC and PifA.
Here is an example found in the RefSeq database:
@@ -75,15 +91,3 @@ end
style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
## Relevant abstracts
::relevant-abstracts
---
items:
- doi: 10.1007/BF00327934
- doi: 10.1016/j.virol.2004.06.001
- doi: 10.1128/jb.173.20.6507-6514.1991
---
::
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