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Activator: Unknown
Effector: Unknown
PFAM: PF13676
contributors:
- Lucas Paoli
relevantAbstracts:
- doi: 10.1016/j.chom.2022.02.018
---
# Rst_TIR-NLR
## Description
The Rst_TIR-NLR system is named after the first author of the paper describing it (Rousset et al. 2022) and the domains of the only protein it contains (TIR, toll-interleukin-1 receptor, and NLR, nucleotide-binding leucine rich repeat receptor) :ref{doi=10.1016/j.chom.2022.02.018}.
This system is very similar to other bacterial defense systems: bNACHT (https://defense-finder.pasteur.cloud/wiki/defense-systems/nlr), CARD_NLR (https://defense-finder.pasteur.cloud/wiki/defense-systems/card_nlr), Avs (AVAST) (https://defense-finder.pasteur.cloud/wiki/defense-systems/avs).
## Molecular mechanisms
As far as we are aware, the molecular mechanism is unknown. However, the molecular mechanism of closely related systems was previously studied. See bNACHT (https://defense-finder.pasteur.cloud/wiki/defense-systems/nlr), CARD_NLR (https://defense-finder.pasteur.cloud/wiki/defense-systems/card_nlr) and Avs (AVAST) (https://defense-finder.pasteur.cloud/wiki/defense-systems/avs)
## Example of genomic structure
The Rst_TIR-NLR system is composed of one protein: TIR.
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## Relevant abstracts
::relevant-abstracts
---
items:
- doi: 10.1016/j.chom.2022.02.018
---
::
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