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Commit 0de4e879 authored by Fabien  MAREUIL's avatar Fabien MAREUIL
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...@@ -14,16 +14,16 @@ ...@@ -14,16 +14,16 @@
<div id="content" class="main-content"> <div id="content" class="main-content">
<div class="section"> <div class="section">
<main role="main"> <main role="main">
<h1 class="page-title"> IPPI - DB </h1> <h1 class="page-title"> iPPI - DB </h1>
<div class="tabs"></div> <div class="tabs"></div>
<div class="main__inner"> <div class="main__inner">
<div class="region region-content"> <div class="region region-content">
<div class="page-intro"> <div class="page-intro">
{% block pageintro %} {% block pageintro %}
IPPI-DB is a database of modulators of protein-protein interactions. It contains iPPI-DB is a database of modulators of protein-protein interactions. It contains
exclusively small molecules and therefore no peptides. The data are retrieved from exclusively small molecules and therefore no peptides. The data are retrieved from
the literature either peer reviewed scientific articles or world patents. the literature either peer reviewed scientific articles or world patents.
A large variety of data is stored within IPPI-DB: structural, pharmacological, A large variety of data is stored within iPPI-DB: structural, pharmacological,
binding and activity profile, pharmacokinetic and cytotoxicity when available, as binding and activity profile, pharmacokinetic and cytotoxicity when available, as
well as some data about the PPI targets themselves. well as some data about the PPI targets themselves.
{% endblock %} {% endblock %}
......
...@@ -179,7 +179,7 @@ ...@@ -179,7 +179,7 @@
<p>Table of descriptors for each pocket, detected by Volsite (<a title="Desaphy J, Azdimousa K, Kellenberger E, Rognan D. <p>Table of descriptors for each pocket, detected by Volsite (<a title="Desaphy J, Azdimousa K, Kellenberger E, Rognan D.
Comparison and druggability prediction of protein-ligand binding sites from pharmacophore-annotated cavity shapes. J Chem Inf Model. 2012 Aug 27;52(8):2287-99." href="https://doi.org/10.1021/ci300184x" target="_blank">Desaphy et al., 2012</a>). Comparison and druggability prediction of protein-ligand binding sites from pharmacophore-annotated cavity shapes. J Chem Inf Model. 2012 Aug 27;52(8):2287-99." href="https://doi.org/10.1021/ci300184x" target="_blank">Desaphy et al., 2012</a>).
Click on <i class="far fa-plus-square"></i> icon to see closest pockets, based on the Pocket Similarity Index. Click on <i class="far fa-plus-square"></i> icon to see closest pockets, based on the Pocket Similarity Index.
Pocket name is built with: pdb id @ pocket's chain id | name / pocket number :: Pocket name is built with: pdb id / pocket's chain id | name / pocket number ::
partner ligand id or chain id | name partner ligand id or chain id | name
</p> </p>
</div> </div>
...@@ -202,7 +202,7 @@ Comparison and druggability prediction of protein-ligand binding sites from phar ...@@ -202,7 +202,7 @@ Comparison and druggability prediction of protein-ligand binding sites from phar
<table id="cavitiestable" class="table table-hover shadow table-responsive table-sm zui-table table-header-rotated"> <table id="cavitiestable" class="table table-hover shadow table-responsive table-sm zui-table table-header-rotated">
<thead class="thead-light"> <thead class="thead-light">
<tr> <tr>
<th class="zui-sticky-col" title="PDB ID @ Chain ID | name / Pocket :: Partner ID | name" scope="col"><div><span>Pockets</span></div></th> <th class="zui-sticky-col" title="PDB ID / Chain ID | name / Pocket :: Partner ID | name" scope="col"><div><span>Pockets</span></div></th>
<th class="rotate-45" title="HD: Heterodimer, PL: Protein ligand" scope="col"><div><span>Type</span></div></th> <th class="rotate-45" title="HD: Heterodimer, PL: Protein ligand" scope="col"><div><span>Type</span></div></th>
<th class="rotate-45" title="Volume in Aˆ3" scope="col"><div><span>Volume</span></div></th> <th class="rotate-45" title="Volume in Aˆ3" scope="col"><div><span>Volume</span></div></th>
<th class="rotate-45" title="Normalized Moment of Inertia PMX/PMZ" scope="col"><div><span>NPR1</span></div></th> <th class="rotate-45" title="Normalized Moment of Inertia PMX/PMZ" scope="col"><div><span>NPR1</span></div></th>
...@@ -241,7 +241,7 @@ Comparison and druggability prediction of protein-ligand binding sites from phar ...@@ -241,7 +241,7 @@ Comparison and druggability prediction of protein-ligand binding sites from phar
<i class="far fa-plus-square" style="cursor: pointer;" data-toggle="collapse" data-target=".collapseme{{ chaincount }}_{{ cavcount }}"></i> <i class="far fa-plus-square" style="cursor: pointer;" data-toggle="collapse" data-target=".collapseme{{ chaincount }}_{{ cavcount }}"></i>
<a target="_blank" rel="noopener noreferrer" href="{% url 'cavities' %}?pdbsearch={{ cavity.chain.pdb.code }}">{{ cavity.chain.pdb.code }}</a> <a target="_blank" rel="noopener noreferrer" href="{% url 'cavities' %}?pdbsearch={{ cavity.chain.pdb.code }}">{{ cavity.chain.pdb.code }}</a>
@ /
<span class="dropdown"> <span class="dropdown">
<div class="dropbtn" data-toggle="dropdown" title="uniprot: {{ cavity.chain.protein.uniprot_id }}"> <div class="dropbtn" data-toggle="dropdown" title="uniprot: {{ cavity.chain.protein.uniprot_id }}">
{{ cavity.chain.pdb_chain_id }} | {{ cavity.chain.protein.short_name }} {{ cavity.chain.pdb_chain_id }} | {{ cavity.chain.protein.short_name }}
...@@ -316,7 +316,7 @@ Comparison and druggability prediction of protein-ligand binding sites from phar ...@@ -316,7 +316,7 @@ Comparison and druggability prediction of protein-ligand binding sites from phar
<th class="zui-sticky-col text-nowrap"> <th class="zui-sticky-col text-nowrap">
<a title="{{ distance.distance|get_zscore:avg_std|floatformat:3|intcomma }}" target="_blank" rel="noopener noreferrer" href="{% url 'cavities' %}?pdbsearch={{ distance.cavity2.chain.pdb.code }}">{{ distance.cavity2.chain.pdb.code }}</a> <a title="{{ distance.distance|get_zscore:avg_std|floatformat:3|intcomma }}" target="_blank" rel="noopener noreferrer" href="{% url 'cavities' %}?pdbsearch={{ distance.cavity2.chain.pdb.code }}">{{ distance.cavity2.chain.pdb.code }}</a>
@ /
<span class="dropdown"> <span class="dropdown">
<div class="dropbtn" data-toggle="dropdown" title="uniprot: {{ distance.cavity2.chain.protein.uniprot_id }}"> <div class="dropbtn" data-toggle="dropdown" title="uniprot: {{ distance.cavity2.chain.protein.uniprot_id }}">
{{ distance.cavity2.chain.pdb_chain_id }} | {{ distance.cavity2.chain.protein.short_name }} {{ distance.cavity2.chain.pdb_chain_id }} | {{ distance.cavity2.chain.protein.short_name }}
...@@ -389,7 +389,7 @@ Comparison and druggability prediction of protein-ligand binding sites from phar ...@@ -389,7 +389,7 @@ Comparison and druggability prediction of protein-ligand binding sites from phar
<tr class="collapse out collapseme{{ chaincount }}_{{ cavcount }}" style="background-color:rgb({{ distance.distance|get_zscore:avg_std|get_color }})"> <tr class="collapse out collapseme{{ chaincount }}_{{ cavcount }}" style="background-color:rgb({{ distance.distance|get_zscore:avg_std|get_color }})">
<th class="zui-sticky-col text-nowrap"> <th class="zui-sticky-col text-nowrap">
<a title="{{ distance.distance|get_zscore:avg_std|floatformat:3|intcomma }}" target="_blank" rel="noopener noreferrer" href="{% url 'cavities' %}?pdbsearch={{ distance.cavity1.chain.pdb.code }}">{{ distance.cavity1.chain.pdb.code }}</a> <a title="{{ distance.distance|get_zscore:avg_std|floatformat:3|intcomma }}" target="_blank" rel="noopener noreferrer" href="{% url 'cavities' %}?pdbsearch={{ distance.cavity1.chain.pdb.code }}">{{ distance.cavity1.chain.pdb.code }}</a>
@ /
<span class="dropdown"> <span class="dropdown">
<div class="dropbtn" data-toggle="dropdown" title="uniprot: {{ distance.cavity1.chain.protein.uniprot_id }}"> <div class="dropbtn" data-toggle="dropdown" title="uniprot: {{ distance.cavity1.chain.protein.uniprot_id }}">
{{ distance.cavity1.chain.pdb_chain_id }} | {{ distance.cavity1.chain.protein.short_name }} {{ distance.cavity1.chain.pdb_chain_id }} | {{ distance.cavity1.chain.protein.short_name }}
......
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