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Commit faf851f4 authored by Cyril  NERIN's avatar Cyril NERIN
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FEAT #96

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......@@ -106,10 +106,26 @@ Creation of the JASS inittable
Once, GWAS summary statistics are harmonized, they are integrated into
one file by the using jass command (see detail in command line usage)
```
jass create-inittable --input-data-path '$GWAS_files_glob_pattern' --init-covariance-path $path_to_covariance_file --regions-map-path $path_to_LD_regions --description-file-path $path_to_gwas_meta_data.csv --init-table-path $path_to_output_inittable
.. code-block:: shell
jass create-inittable --input-data-path '$GWAS_files_glob_pattern' --init-covariance-path $path_to_covariance_file --regions-map-path $path_to_LD_regions --description-file-path $path_to_gwas_meta_data.csv --init-table-path $path_to_output_inittable
Add genes and exons annotation to initTable (optional)
------------------------------------------------------
If you want to avoid a (non-blocking) error in the JASS web interface when performing a local analysis on a region of the genome,
you must add the genes and exons to the InitTable
To do this, you need to download the file: RefSeq Reference Genome Annotation GRCh37 from the website: https://www.ncbi.nlm.nih.gov/genome/guide/human/
before unzipping it on your computer and saving it in the JASS_DATA_DIR folder. Then you can run in a terminal the following command:
.. code-block:: shell
jass add-gene-annotation --gene-data-path GRCh37_latest_genomic.gff --init-table-path $path_to_initTable.hdf5 --gene-csv-path df_gene.csv --exon-csv-path df_exon.csv
```
.. warning::
For this command, it is necessary to specify the full path of initTable.hdf5 even if this file is in the JASS_DATA_DIR folder. You can use the environment variable $JASS_DATA_DIR (Linux) or %JASS_DATA_DIR% (Windows)
The advantage of adding genes and exons in the initTable is to have an additional graph in the web page of the results of the local analysis:
the position of genes and exons in the studied genomic region (see paragraph: **web usage, section B - Analysis by region**)
.. bibliography:: reference.bib
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