rosmerta.md 4.68 KiB
title: RosmerTA
layout: article
tableColumns:
article:
doi: 10.1016/j.chom.2022.09.017
abstract: |
Bacterial anti-phage systems are frequently clustered in microbial genomes, forming defense islands. This property enabled the recent discovery of multiple defense systems based on their genomic co-localization with known systems, but the full arsenal of anti-phage mechanisms remains unknown. We report the discovery of 21 defense systems that protect bacteria from phages, based on computational genomic analyses and phage-infection experiments. We identified multiple systems with domains involved in eukaryotic antiviral immunity, including those homologous to the ubiquitin-like ISG15 protein, dynamin-like domains, and SEFIR domains, and show their participation in bacterial defenses. Additional systems include domains predicted to manipulate DNA and RNA molecules, alongside toxin-antitoxin systems shown here to function in anti-phage defense. These systems are widely distributed in microbial genomes, and in some bacteria, they form a considerable fraction of the immune arsenal. Our data substantially expand the inventory of defense systems utilized by bacteria to counteract phage infection.
Sensor: Unknown
Activator: Unknown
Effector: Unknown
PFAM: PF01381, PF06114, PF12844, PF13443, PF13560
contributors:
- Lucas Paoli
relevantAbstracts:
- doi: 10.1016/j.chom.2022.09.017RosmerTA
Description
The RosmerTA system was found to have antiviral activity and named after Gallo-Roman goddess of fertility by Millman et al. 2022 :ref{doi=10.1016/j.chom.2022.09.017}.
Molecular mechanisms
The RosmerTA system encodes a Zn-peptidase and a toxin of unknown function :ref{doi=10.1016/j.chom.2022.09.017}. One toxin representative has been found to induce membrane depolarization :ref{doi=10.1073/pnas.2305393120}.
Example of genomic structure
The RosmerTA is composed of 2 proteins: RmrT and RmrA. The toxin can vary in sequence and structure.
Here is an example found in the RefSeq database:
