Skip to content
Snippets Groups Projects
Commit 031be32f authored by Jean  CURY's avatar Jean CURY
Browse files

Update lamassu-fam.md

parent 16d0e051
No related branches found
No related tags found
1 merge request!129Update lamassu-fam.md
Pipeline #117210 failed
...@@ -28,7 +28,7 @@ The original types of Lamassu systems are Lamassu Type 1 :ref{doi=10.1126/scienc ...@@ -28,7 +28,7 @@ The original types of Lamassu systems are Lamassu Type 1 :ref{doi=10.1126/scienc
Lamassu has been suggested to be a large family of defense systems, that can be classified into multiple subtypes :ref{doi=10.1016/j.chom.2022.09.017}. Lamassu has been suggested to be a large family of defense systems, that can be classified into multiple subtypes :ref{doi=10.1016/j.chom.2022.09.017}.
These systems all encode the *lmuB* gene, and in most cases also comprise *lmuC*. In addition to these two core genes, Lamassu systems of various subtypes encode a third protein, hypothesized to be the Abi effector protein. This effector can be proteins encoding endonuclease domains, SIR2-domains, or even hydrolase domains :ref{doi=10.1016/j.chom.2022.09.017}. Systems of the extended Lamassu-family can be found in 10% of prokaryotic genomes :ref{doi=10.1016/j.chom.2022.09.017}. These systems all encode the *lmuB* gene, and in most cases also comprise *lmuC*. In addition to these two core genes, Lamassu systems of various subtypes encode a third protein, hypothesized to be the Abi effector protein :ref{doi=10.1101/2022.05.11.491447}. This effector can be proteins encoding endonuclease domains, SIR2-domains, or even hydrolase domains :ref{doi=10.1016/j.chom.2022.09.017}. Systems of the extended Lamassu-family can be found in 10% of prokaryotic genomes :ref{doi=10.1016/j.chom.2022.09.017}.
Lamassu were also described as DdmABC in *Vibrio cholerae* :ref{doi=10.1038/s41586-022-04546-y, 10.1101/2022.11.18.517080}. They were found to be antiplasmids and thus to eliminate plasmids from seventh pandemic *Vibrio cholerae* :ref{doi=10.1038/s41586-022-04546-y}. Lamassu were also described as DdmABC in *Vibrio cholerae* :ref{doi=10.1038/s41586-022-04546-y, 10.1101/2022.11.18.517080}. They were found to be antiplasmids and thus to eliminate plasmids from seventh pandemic *Vibrio cholerae* :ref{doi=10.1038/s41586-022-04546-y}.
......
0% Loading or .
You are about to add 0 people to the discussion. Proceed with caution.
Finish editing this message first!
Please register or to comment