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Commit 31479d38 authored by fltesson's avatar fltesson
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go back to NLR to stick with DefenseFinder output

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title: bNacht title: NLR
layout: article layout: article
tableColumns: tableColumns:
article: article:
...@@ -16,14 +16,17 @@ relevantAbstract: ...@@ -16,14 +16,17 @@ relevantAbstract:
- doi: 10.1016/j.cell.2023.04.015 - doi: 10.1016/j.cell.2023.04.015
--- ---
# bNacht # NLR / bNACHT
## Description ## Description
This NLR like system is also known as the bNACHT systems.
Several proteins containing a NACHT module were found to have anti-phage activity. NACHT modules are also found in metazoans, where they play a role in innate immunity. Several proteins containing a NACHT module were found to have anti-phage activity. NACHT modules are also found in metazoans, where they play a role in innate immunity.
bNacht systems have some similarities with other defense systems: bNacht systems have some similarities with other defense systems:
[CARD_NLR](/defense-systems/card_nlr) , [Rst_TIR-NLR](/defense-systems/rst_tir-nlr), [Avs](/defense-systems/avs). [CARD_NLR](/defense-systems/card_nlr) , [Rst_TIR-NLR](/defense-systems/rst_tir-nlr), [Avs](/defense-systems/avs).
## Molecular mechanism ## Molecular mechanism
Bacterial NACHT module-containing proteins (bNACHT) encompass a C-terminal sensor, a central NACHT module, and N-terminal effector modules. The N-terminal effectors associated with bNACHT proteins are diverse, and include domains that have been previously described to be involved in other defense systems {doi=10.1016/j.cell.2023.04.015} Bacterial NACHT module-containing proteins (bNACHT) encompass a C-terminal sensor, a central NACHT module, and N-terminal effector modules. The N-terminal effectors associated with bNACHT proteins are diverse, and include domains that have been previously described to be involved in other defense systems {doi=10.1016/j.cell.2023.04.015}
As far as we are aware, the precise molecular mechanism of bNACHT is unknown. As far as we are aware, the precise molecular mechanism of bNACHT is unknown.
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