add information RloC

content/3.defense-systems/rloc.md

@@ -10,12 +10,25 @@ tableColumns:
     Activator: Unknown
     Effector: Nucleic acid degrading
     PFAM: PF13166
+contributors: 
+  - Aude Bernheim
+  - Florian Tesson
 relevantAbstracts:
-    - doi: 10.1111/j.1365-2958.2008.06387.x
-    - doi: 10.1111/mmi.13074
+  - doi: 10.1111/j.1365-2958.2008.06387.x
 ---
 
 # RloC
+
+## Description
+
+RloC is a distant homolog of the tRNALys anticodon nuclease (ACNase) [PrrC](/defense-systems/prrc). RloC shares the ABC ATPase motifs and catalytic ACNase triad with PrrC, but it possesses a unique zinc-hook/coiled-coil insert. This distinctive feature results in its ATPase domain bearing similarity to Rad50 and other DNA repair proteins.Contrary to PrrC RloC is rarely linked to a type I R-M system. RloC activity was not directly demonstrated on phages but hypothesized through its similar features to PrrC :ref{doi=10.1111/j.1365-2958.2008.06387.x}.
+
+This system was not experimentally validated but is still considered as a defense system because of its homology with [PrrC](/defense-systems/prrc) and its abundance in [defense islands](/general-concepts/defense-islands). Of the RloC system detected by DefenseFinder around 40% are close to at least one known defense system (20 proteins on each side).
+
+## Molecular Mechanism
+
+RloC was shown to function by tRNA cleavage (wobble nucleotide-excising and Zn++-responsive tRNase) :ref{doi=10.1006/jmbi.1995.0343}. However, such activity was not directly shown on a phage
+ Zinc hook seems to regulate the nuclease function.
 ## Example of genomic structure
 
 The RloC is composed of 1 protein: RloC.