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Commit 93eaf0d8 authored by Remi  PLANEL's avatar Remi PLANEL
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Fix error links

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1 merge request!7K8s deploy
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...@@ -16,6 +16,7 @@ stages: ...@@ -16,6 +16,7 @@ stages:
image: docker:24 image: docker:24
variables: variables:
CONTEXT: "." CONTEXT: "."
DOCKERFILE: "Dockerfile"
before_script: before_script:
- i=0; while [ "$i" -lt 12 ]; do docker info && break; sleep 5; i=$(( i + 1 )) ; done - i=0; while [ "$i" -lt 12 ]; do docker info && break; sleep 5; i=$(( i + 1 )) ; done
- docker login -u "$CI_REGISTRY_USER" -p "$CI_REGISTRY_PASSWORD" $CI_REGISTRY - docker login -u "$CI_REGISTRY_USER" -p "$CI_REGISTRY_PASSWORD" $CI_REGISTRY
...@@ -41,9 +42,7 @@ stages: ...@@ -41,9 +42,7 @@ stages:
build:dev:nuxt: build:dev:nuxt:
extends: .build extends: .build
variables: variables:
DOCKERFILE: "Dockerfile"
IMAGE_NAME: "df-wiki" IMAGE_NAME: "df-wiki"
CONTEXT: "./"
rules: rules:
- if: $CI_COMMIT_BRANCH != "main" - if: $CI_COMMIT_BRANCH != "main"
......
...@@ -11,23 +11,7 @@ The knowledge of anti-phage defense systems is ever expanding. The spectacular i ...@@ -11,23 +11,7 @@ The knowledge of anti-phage defense systems is ever expanding. The spectacular i
::list-systems
---
systems:
- system: Paris
dois:
- 10.1101/2021.01.21.427644
- system: AbiE
dois:
- 10.1093/nar/gkt1419
- system: AVAST
dois:
- 10.1126/science.aba0372
- system: RM
dois:
- 10.1093/nar/gku734
---
::
......
...@@ -4,13 +4,13 @@ title: BREX ...@@ -4,13 +4,13 @@ title: BREX
## Description ## Description
BREX (for Bacteriophage Exclusion) is a family of anti-phage defense systems. BREX systems are active against both lytic and lysogenic phages. They allow phage adsorption but block phage DNA replication, and are considered to be [RM](/list_defense_systems/RM)-like systems (1,2). BREX systems are found in around 10% of sequenced microbial genomes (1). BREX (for Bacteriophage Exclusion) is a family of anti-phage defense systems. BREX systems are active against both lytic and lysogenic phages. They allow phage adsorption but block phage DNA replication, and are considered to be [RM](/defense-systems/rm)-like systems (1,2). BREX systems are found in around 10% of sequenced microbial genomes (1).
BREX systems can be divided into six subtypes, and are encoded by 4 to 8 genes, some of these genes being mandatory while others are subtype-specific (1). BREX systems can be divided into six subtypes, and are encoded by 4 to 8 genes, some of these genes being mandatory while others are subtype-specific (1).
## Molecular mechanism ## Molecular mechanism
*B. cereus* BREX Type 1 system was reported to methylate target motifs in the bacterial genome (1). The methylation activity of this system has been hypothesized to allow for self from non-self discrimination, as it is the case for Restriction-Modification ([RM)](/list_defense_systems/RM) systems. *B. cereus* BREX Type 1 system was reported to methylate target motifs in the bacterial genome (1). The methylation activity of this system has been hypothesized to allow for self from non-self discrimination, as it is the case for Restriction-Modification ([RM)](/defense-systems/rm) systems.
However, the mechanism through which BREX Type 1 systems defend against phages is distinct from RM systems, and does not seem to degrade phage nucleic acids (1). However, the mechanism through which BREX Type 1 systems defend against phages is distinct from RM systems, and does not seem to degrade phage nucleic acids (1).
......
...@@ -6,7 +6,7 @@ title: DISARM ...@@ -6,7 +6,7 @@ title: DISARM
DISARM (Defense Island System Associated with Restriction-Modification) is a defense system widespread in prokaryotes, encoded by a 5-gene cassette. DISARM provides broad protection against double-stranded DNA phages, including siphophages, myophages, and podophages (1,3). DISARM (Defense Island System Associated with Restriction-Modification) is a defense system widespread in prokaryotes, encoded by a 5-gene cassette. DISARM provides broad protection against double-stranded DNA phages, including siphophages, myophages, and podophages (1,3).
It was reported to restrict incoming phage DNA and methylate the bacterial host DNA, which could be responsible for self from non-self discrimination (1). This suggests a [Restriction-Modification](/list_defense_systems/RM)-like (RM-like) mechanism, yet some pieces of experimental evidence hint that DISARM actually acts through a novel and uncharacterized molecular mechanism (1,2). It was reported to restrict incoming phage DNA and methylate the bacterial host DNA, which could be responsible for self from non-self discrimination (1). This suggests a [Restriction-Modification](/defense-systems/rm)-like (RM-like) mechanism, yet some pieces of experimental evidence hint that DISARM actually acts through a novel and uncharacterized molecular mechanism (1,2).
## Molecular mechanism ## Molecular mechanism
......
...@@ -6,7 +6,7 @@ title: Rst_PARIS ...@@ -6,7 +6,7 @@ title: Rst_PARIS
PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. PARIS is found in 4% of prokaryotic genomes. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion (1). PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. PARIS is found in 4% of prokaryotic genomes. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion (1).
This system relies on an unknown [Abortive infection](/general_concepts/Abi) mechanism to trigger growth arrest upon sensing a phage-encoded protein (Ocr). Interestingly, the Ocr protein has been found to inhibit R-M systems and BREX systems, making PARIS a suitable defense mechanism against RM resistant and/or BREX resistant phages (1, 2, 3). This system relies on an unknown [Abortive infection](/general-concepts/abortive-infection) mechanism to trigger growth arrest upon sensing a phage-encoded protein (Ocr). Interestingly, the Ocr protein has been found to inhibit R-M systems and BREX systems, making PARIS a suitable defense mechanism against RM resistant and/or BREX resistant phages (1, 2, 3).
## Example of genomic structure ## Example of genomic structure
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