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## Description
The Rst_TIR-NLR system is named after the first author of the paper describing it (Rousset et al. 2022) and the domains of the only protein it contains (TIR, toll-interleukin-1 receptor, and NLR, NOD-like receptor) :ref{doi=10.1016/j.chom.2022.02.018}.
The Rst_TIR-NLR system is named after the first author of the paper describing it (Rousset et al. 2022) and the domains of the only protein it contains (TIR, toll-interleukin-1 receptor, and NLR, nucleotide-binding leucine rich repeat receptor) :ref{doi=10.1016/j.chom.2022.02.018}.
This system is very similar to other bacterial defense systems: bNACHT (https://defense-finder.pasteur.cloud/wiki/defense-systems/nlr), CARD_NLR (https://defense-finder.pasteur.cloud/wiki/defense-systems/card_nlr), Avs (AVAST) (https://defense-finder.pasteur.cloud/wiki/defense-systems/avs).
## Molecular mechanisms
As far as we are aware, the molecular mechanism is unknown.
As far as we are aware, the molecular mechanism is unknown. However, the molecular mechanism of closely related systems was previously studied. See bNACHT (https://defense-finder.pasteur.cloud/wiki/defense-systems/nlr), CARD_NLR (https://defense-finder.pasteur.cloud/wiki/defense-systems/card_nlr) and Avs (AVAST) (https://defense-finder.pasteur.cloud/wiki/defense-systems/avs)
## Example of genomic structure
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