Tool used to compute the covariance test on a set of predictors, presented in this paper : hhttps://academic.oup.com/bib/article/25/4/bbae272/7690346 MANOCCA (Multivariate ANalysis of Conditional CovAriance) performs the covariance test : $Cov(Y_1,Y_2) ~ X + C$, as well as the multivariate version with more than two Y outcomes. In quick words, MANOCCA (Multivariate ANalysis of Conditional CovAriance) is a test of differences of covariance with regard to a predictor. The test is orthogonal to mean and variance effects, and will only grasp covariance effects.
Tool used to compute the covariance test on a set of predictors, presented in this paper : https://academic.oup.com/bib/article/25/4/bbae272/7690346 MANOCCA (Multivariate ANalysis of Conditional CovAriance) performs the covariance test : $Cov(Y_1,Y_2) \~ X + C$, as well as the multivariate version with more than two Y outcomes. In quick words, MANOCCA (Multivariate ANalysis of Conditional CovAriance) is a test of differences in correlations/covariance with regard to a predictor. The test is orthogonal to mean and variance effects, and will only grasp covariance effects.
One application of the MANOCCA test to detect co-abunding human gut microbiome communities can be found in this preprint : https://www.medrxiv.org/content/10.1101/2024.04.30.24306630v1.full
Note : If all outcomes are centered and scaled, then $Corr(Y_1, Y_2) = Cov(Y_1,Y_2)$ and MANOCCA can test for changes in correlation. The subtleties of covariance vs correlation are discussed in the main draft and supplements of the paper above.
Author : Christophe BOETTO
Author : Christophe BOETTO
Archived commit pinned for the article https://academic.oup.com/bib/article/25/4/bbae272/7690346 in case the tool evolves in the future : 6d76df07
To go to this specific commit do :
- git clone <manocca_https_link>
- cd manocca
- git reset --hard 6d76df07
# Contents
# Contents
The current repository contains the Python and R versions of MANOCCA. The python is more detailed than the R version, but I will work on it.
The current repository contains the Python and R versions of MANOCCA. The python is more detailed than the R version, but they both provide the same test.
