updates

README.md

@@ -4,7 +4,7 @@ This repository contains the code used in the paper:
 Lun Cui, Antoine Vigouroux, Francois Rousset, Hugo Varet, Varun Khanna & David Bikard
 
 
-In this study we designed a library of 84215 unique guide RNAs targeting random positions 
+In this study we designed a library of  guide RNAs targeting random positions
 along the genome of E. coli MG1655, with the simple requirement of a “NGG” PAM. The library 
 contains an average of 19 targets per gene. A pool of guide RNAs obtained through on-chip 
 oligo synthesis was cloned under the control of a constitutive promoter on plasmid psgRNA 
@@ -14,7 +14,7 @@ over 17 generations with anhydrotetracycline (aTc). The effect of each guide on
 the fold change in abundance (log2FC) of the guide RNA in the library 
 during the course of the experiment, as measured through deep sequencing of the library.
 
-The log2FC data for all guides in the screen can be found in the file Supplementary_table_6-screen_data.csv
+The log2FC data for all guides in the screen can be found in the file screen_data.csv
 
 The analysis is divided in three jupyter notebooks:
 * Effect of dCas9 binding position and orientation.ipynb