Merge branch 'ftesson_shosta_request' into 'main'

shosta_hackaton

See merge request !112

content/3.defense-systems/shosta.md

@@ -10,9 +10,23 @@ tableColumns:
     Activator: Unknown
     Effector: Unknown
     PFAM: PF02481
+relevantAbstracts:
+  - doi: 10.1016/j.chom.2022.09.017
+  - doi: 10.1016/j.chom.2022.02.018
+  - doi: 10.1101/gr.133850.111
 ---
 
 # ShosTA
+
+## Description
+
+ShosTA system was first described as a Toxin/Antitoxin system in 2012 :ref{doi=10.1101/gr.133850.111} without demonstration of antiphage activity. In 2022, a paper described the same system as "DprA + PRTase" inside P2 like prophages and prooves its antiphage activity. Finally, the antiphage activity was also prooved in another study with the original name ShosTA :ref{doi=10.1016/j.chom.2022.09.017}.
+
+This system is composed of two protein: ShosT and ShosA encoding for Hydrolase/PRTase and DprA (nucleotid binding) respectively.
+
+## Molecular mechanism
+The ShosTA system is a toxin (ShosT) antitoxin (ShosA) system. The domains of ShosT (Hydrolase and PRTase) allows us to hypothesize a toxicity linked to host protein degradation.
+
 ## Example of genomic structure
 
 The ShosTA is composed of 2 proteins: ShosA and ShosT.
@@ -88,15 +102,5 @@ end
     style Title3 fill:none,stroke:none,stroke-width:none
     style Title4 fill:none,stroke:none,stroke-width:none
 </mermaid>
-## Relevant abstracts
 
-::relevant-abstracts
----
-items:
-    - doi: 10.1016/j.chom.2022.09.017
-    - doi: 10.1016/j.chom.2022.09.017
-    - doi: 10.1101/gr.133850.111
-
----
-::